氧化钬纳米颗粒的毒性及T₂加权磁共振成像潜力
Toxicity and T₂-Weighted Magnetic Resonance Imaging Potentials of Holmium Oxide Nanoparticles.
作者信息
Atabaev Timur Sh, Shin Yong Cheol, Song Su-Jin, Han Dong-Wook, Hong Nguyen Hoa
机构信息
Department of Physics and Astronomy, Seoul National University, Seoul 08826, Korea.
Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 46241, Korea.
出版信息
Nanomaterials (Basel). 2017 Aug 7;7(8):216. doi: 10.3390/nano7080216.
Abstract
In recent years, paramagnetic nanoparticles (NPs) have been widely used for magnetic resonance imaging (MRI). This paper reports the fabrication and toxicity evaluation of polyethylene glycol (PEG)-functionalized holmium oxide (Ho₂O₃) NPs for potential ₂-weighted MRI applications. Various characterization techniques were used to examine the morphology, structure and chemical properties of the prepared PEG-Ho₂O₃ NPs. MRI relaxivity measurements revealed that PEG-Ho₂O₃ NPs could generate a strong negative contrast in ₂-weighted MRI. The pilot cytotoxicity experiments showed that the prepared PEG-Ho₂O₃ NPs are biocompatible at concentrations less than 16 μg/mL. Overall, the prepared PEG-Ho₂O₃ NPs have potential applications for ₂-weighted MRI imaging.
摘要
近年来，顺磁性纳米粒子（NPs）已被广泛用于磁共振成像（MRI）。本文报道了用于潜在的T₂加权MRI应用的聚乙二醇（PEG）功能化氧化钬（Ho₂O₃）纳米粒子的制备及毒性评估。采用各种表征技术来研究制备的PEG-Ho₂O₃纳米粒子的形态、结构和化学性质。MRI弛豫率测量表明，PEG-Ho₂O₃纳米粒子在T₂加权MRI中可产生强烈的负对比度。初步细胞毒性实验表明，制备的PEG-Ho₂O₃纳米粒子在浓度低于16μg/mL时具有生物相容性。总体而言，制备的PEG-Ho₂O₃纳米粒子在T₂加权MRI成像方面具有潜在应用。
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