Lupu Mihaela-Adi, Gradisteanu Pircalabioru Gratiela, Chifiriuc Mariana-Carmen, Albulescu Radu, Tanase Cristiana
SC Sanimed International Impex SRL, 087040 Bucharest, Romania.
Research Institute of University of Bucharest (ICUB), 050098 Bucharest, Romania.
Exp Ther Med. 2020 Jul;20(1):12-17. doi: 10.3892/etm.2019.8342. Epub 2019 Dec 17.
Ageing is a complex, multi-step process which involves, among others loss of collagen and elastin. Collagen is found in large amounts in the body, especially in the dermis layer. These fibers provide the skin's normal strength, hydration and mechanical properties. Collagen is largely available, as it can be extracted from many animal sources, it can be easily absorbed upon topical administration, hence it is largely used in the cosmetic and pharmaceutical industry for the treatment of premature aging. Bioactive peptides, such as collagen hydrolyzate, are among the most used ingredients for the development of nutraceuticals - food or food ingredients that have defined physiological effects. Numerous studies have demonstrated that peptides resulted from ingestion of hydrolysate collagen and detected in the blood stream have chemotactic properties for skin fibroblasts, helping the skin restoration process. The purpose of this minireview is to present an update on the use of hydrolyzed collagen for skin care.
衰老 是一个复杂的多步骤过程，其中包括胶原蛋白和弹性蛋白的流失。胶原蛋白在体内大量存在，尤其是在真皮层。这些纤维赋予皮肤正常的强度、水分含量和机械性能。胶原蛋白来源广泛，因为它可以从多种动物来源中提取，局部给药时易于吸收，因此在化妆品和制药行业中广泛用于治疗早衰。生物活性肽，如胶原蛋白水解物，是开发营养保健品（即具有明确生理作用的食品或食品成分）最常用的成分之一。大量研究表明，摄入水解胶原蛋白后在血流中检测到的肽对皮肤成纤维细胞具有趋化特性，有助于皮肤修复过程。本综述的目的是介绍水解胶原蛋白在皮肤护理方面应用的最新情况。
