Ibarra-Reynoso Lorena Del Rocio, López-Lemus Hilda Lissette, Garay-Sevilla Ma Eugenia, Malacara Juan Manuel
Department of Medical Sciences, University of Guanajuato, Campus León, León, Mexico.
Obes Facts. 2017;10(4):332-340. doi: 10.1159/000476069. Epub 2017 Aug 5.
We examined the effect of restriction of foods with high fructose content in obese school children.
In a clinical study, we selected 54 obese children 6 to 11 years old with high fructose consumption (>70 g/day) in order indicate dietary fructose restriction (<20 g/day) for 6 weeks. Anthropometry, liver ultrasound as well as glucose, insulin, lipids, leptin, IGFBP1, and RBP4 serum levels were collected.
The group of children had 80% adherence and reported decreased fructose consumption (110 ± 38.6 to 11.4 ± 12.0 g/day) and also a significant decrease in caloric (2,384 ± 568 to 1,757 ± 387 kcal/day) and carbohydrate consumption (302 ± 80.4 to 203 ± 56.0 g/day). The severity of steatosis improved significantly after fructose restriction (p < 0.000001). However, no changes in BMI, systolic blood pressure, or diastolic blood pressure were found. Only triglyceride levels decreased (1.44 ± 0.43 to 1.31 ± 0.38 mmol/l), High-densitiy lipoprotein cholesterol showed a marginal increase (1.45 ± 0.19 to 1.56 ± 0.44 mmol/l). Insulin resistance and RBP4 did not change.
In school children, the restriction of high fructose foods with a decrease of caloric and carbohydrate intake at 6 weeks did not induce weight loss; however, triglyceride levels and hepatic steatosis decreased. Differences with other studies in regard to weight loss may be explained by adaptive changes on metabolic expenditure.
我们研究了限制肥胖学童高果糖含量食物的摄入所产生的影响。
在一项临床研究中，我们选取了54名6至11岁的肥胖儿童，他们果糖摄入量高（>70克/天），旨在表明进行为期6周的饮食果糖限制（<20克/天）。收集人体测量数据、肝脏超声检查结果以及血糖、胰岛素、血脂、瘦素、胰岛素样生长因子结合蛋白1（IGFBP1）和视黄醇结合蛋白4（RBP4）的血清水平。
该组儿童的依从率为80%，报告称果糖摄入量减少（从110±38.6克/天降至11.4±12.0克/天），热量摄入（从2384±568千卡/天降至1757±387千卡/天）和碳水化合物摄入量（从302±80.4克/天降至203±56.0克/天）也显著下降。果糖限制后，脂肪变性的严重程度显著改善（p<0.000001）。然而，未发现体重指数、收缩压或舒张压有变化。仅甘油三酯水平下降（从1.44±0.43毫摩尔/升降至1.31±0.38毫摩尔/升），高密度脂蛋白胆固醇略有升高（从1.45±0.19毫摩尔/升升至1.56±0.44毫摩尔/升）。胰岛素抵抗和RBP4未发生变化。
在学童中，6周内限制高果糖食物并减少热量和碳水化合物摄入并未导致体重减轻；然而，甘油三酯水平和肝脏脂肪变性有所下降。与其他关于体重减轻的研究存在差异，这可能是由代谢消耗的适应性变化所解释的。
