Spencer G S, Harvey S, Audsley A R, Hallett K G, Kestin S
Comp Biochem Physiol A Comp Physiol. 1986;85(3):553-6. doi: 10.1016/0300-9629(86)90445-7.
The effect of both active passive immunization against somatostatin on growth rate and growth hormone levels was studied in chickens. Passive immunization against somatostatin by administration of antiserum had no effect on rate of growth of chickens and no persistent effect on circulating growth hormone (GH) levels. In acute experiments, administration of anti-somatostatin serum caused a marked elevation of GH levels in chickens at both 4 and 8 weeks of age, but the relative stimulation was greater in the older birds. Active immunization against somatostatin significantly stimulated growth rate in chickens, but was not shown to have a clear effect on circulating GH levels. These data suggest that somatostatin control over GH secretion may not be fully developed in the chicken at 4 weeks of age, but that immuno-neutralization of somatostatin can produce an increase rate of growth in chickens similar to that seen in mammals.
研究了对鸡进行生长抑素主动和被动免疫对生长速率和生长激素水平的影响。通过给予抗血清对生长抑素进行被动免疫，对鸡的生长速率没有影响，对循环生长激素（GH）水平也没有持续影响。在急性实验中，给予抗生长抑素血清使4周龄和8周龄的鸡的GH水平显著升高，但年龄较大的鸡相对刺激更大。对生长抑素进行主动免疫显著刺激了鸡的生长速率，但未显示对循环GH水平有明显影响。这些数据表明，4周龄鸡体内生长抑素对GH分泌的控制可能尚未完全发育，但生长抑素的免疫中和可使鸡的生长速率增加，类似于在哺乳动物中观察到的情况。
