Keat A, Thomas B, Dixey J, Osborn M, Sonnex C, Taylor-Robinson D
Lancet. 1987 Jan 10;1(8524):72-4. doi: 10.1016/s0140-6736(87)91910-6.
Reactive inflammatory arthritis is a common sequel to sexually acquired non-gonococcal genital-tract infection. Approximately 50% of cases are associated with Chlamydia trachomatis infection in the genital tract, although conventional cultures of joint material are sterile. Synovium, synovial-fluid cells, or both, from eight patients with sexually acquired reactive arthritis (SARA) and eight with knee effusions associated with other rheumatic diseases were examined by means of a fluorescein-labelled monoclonal antibody to C trachomatis ('Micro Trak'; Syva). Typical chlamydial elementary bodies were seen in joint material from five patients with SARA but in none of the controls. An inclusion-like cluster of elementary bodies was seen in one synovial biopsy sample. All five patients had high titres of serum chlamydial antibody. It is likely that the synovitis of SARA results directly from the presence of chlamydial elementary bodies in the joint.
反应性炎性关节炎是性传播非淋菌性生殖道感染常见的后遗症。尽管关节材料的传统培养结果为无菌，但约50%的病例与生殖道沙眼衣原体感染有关。采用抗沙眼衣原体荧光素标记单克隆抗体（“Micro Trak”；Syva公司）对8例性传播反应性关节炎（SARA）患者及8例与其他风湿性疾病相关的膝关节积液患者的滑膜、滑膜液细胞或两者进行检测。在5例SARA患者的关节材料中发现了典型的衣原体原体，但对照组均未发现。在一份滑膜活检样本中发现了类似包涵体的原体簇。所有5例患者血清衣原体抗体滴度均较高。SARA的滑膜炎很可能直接由关节中衣原体原体的存在所致。
