School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai 264005, China.
State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Acta Pharmacol Sin. 2018 Jan;39(1):132-139. doi: 10.1038/aps.2017.109. Epub 2017 Aug 10.
Cancer metastasis is responsible for over 90% of breast cancer-related deaths, and inhibiting lymph node metastasis is an option to treat metastatic disease. Herein, we report the use of IR-780-loaded polymeric micelles (IPMs) for effective photothermal therapy (PTT) of breast cancer lymphatic metastasis. The IPMs were nanometer-sized micelles with a mean diameter of 25.6 nm and had good stability in simulated physiological solutions. Under 808-nm laser irradiation, IPMs exhibited high heat-generating capability in both in vitro and in vivo experiments. After intravenous injection, IPMs specifically accumulated in the tumor and metastatic lymph nodes and penetrated into these tissues. Moreover, a single IPMs treatment plus laser irradiation significantly inhibited primary tumor growth and suppressed lymphatic metastasis by 88.2%. Therefore, IPMs are an encouraging platform for PTT applications in treatment of metastatic breast cancer.
癌症转移是导致 90%以上乳腺癌相关死亡的原因，而抑制淋巴结转移是治疗转移性疾病的一种选择。在此，我们报告了使用负载 IR-780 的聚合物胶束（IPMs）进行有效的光热治疗（PTT）乳腺癌淋巴转移。IPMs 是纳米级的胶束，平均直径为 25.6nm，在模拟生理溶液中具有良好的稳定性。在 808nm 激光照射下，IPMs 在体外和体内实验中均表现出高热产生能力。静脉注射后，IPMs 特异性地在肿瘤和转移的淋巴结中积聚，并渗透到这些组织中。此外，单次 IPMs 治疗加激光照射显著抑制了原发肿瘤的生长，并抑制了 88.2%的淋巴转移。因此，IPMs 是一种有前途的 PTT 平台，可用于治疗转移性乳腺癌。
