Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
Institute for Risk Analysis and Risk Communication, University of Washington, Seattle, WA, USA.
Int J Environ Res Public Health. 2020 Feb 25;17(5):1479. doi: 10.3390/ijerph17051479.
The exposome provides a conceptual model for identifying and characterizing lifetime environmental exposures and resultant health effects. In this study, we applied key exposome concepts to look specifically at the neurodevelopmental pesticide exposome, which focuses on exposures to pesticides that have the potential to cause an adverse neurodevelopmental impact. Using household dust samples from a children's agricultural cohort located in the Yakima Valley of Washington state, we identified 87 individual pesticides using liquid chromatography-tandem mass spectrometry. A total of 47 of these have evidence of neurotoxicity included in the Environmental Protection Agency (EPA) (re)registration materials. We used a mixed effects model to model trends in pesticide exposure. Over the two study years (2005 and 2011), we demonstrate a significant decrease in the neurodevelopmental pesticide exposome across the cohort, but particularly among farmworker households. Additional analysis with a non-parametric binomial analysis that weighted the levels of potentially neurotoxic pesticides detected in household dust by their reference doses revealed that the decrease in potentially neurotoxic pesticides was largely a result of decreases in some of the most potent neurotoxicants. Overall, this study provides evidence that the neurodevelopmental pesticide exposome framework is a useful tool in assessing the effectiveness of specific interventions in reducing exposure as well as setting priorities for future targeted actions.
外核组学为识别和描述终生环境暴露及其对健康影响提供了一个概念模型。在这项研究中，我们应用了外核组学的关键概念，专门研究神经发育性农药外核组学，其重点是接触具有潜在不良神经发育影响的农药。我们使用来自华盛顿州雅基马谷儿童农业队列的家庭灰尘样本，使用液相色谱-串联质谱法识别了 87 种单独的农药。其中有 47 种农药在环境保护局（EPA）（重新）注册材料中被证明具有神经毒性。我们使用混合效应模型来模拟农药暴露的趋势。在两个研究年份（2005 年和 2011 年）中，我们在整个队列中，特别是在农场工人家庭中，发现神经发育性农药外核组学显著减少。对家庭灰尘中检测到的潜在神经毒性农药进行加权分析的非参数二项式分析显示，潜在神经毒性农药的减少主要是由于一些最有效的神经毒素的减少。总的来说，这项研究提供了证据表明，神经发育性农药外核组学框架是评估特定干预措施减少暴露效果以及为未来有针对性的行动确定优先事项的有用工具。
