Bustos Victor, Partridge Linda
Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931, Cologne, Germany.
Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931, Cologne, Germany; Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK.
Trends Biochem Sci. 2017 Oct;42(10):812-823. doi: 10.1016/j.tibs.2017.07.001. Epub 2017 Aug 9.
Aging is the single greatest risk factor for the development of disease. Understanding the biological molecules and mechanisms that modulate aging is therefore critical for the development of health-maximizing interventions for older people. The effect of fats on longevity has traditionally been disregarded as purely detrimental. However, new studies are starting to uncover the possible beneficial effects of lipids working as signaling molecules on health and longevity. These studies highlight the complex links between aging and lipid signaling. In this review we summarize accumulating evidence that points to changes in lipid metabolism, and in particular lipid signaling, as an underlying mechanism for healthy aging.
衰老是疾病发生的最大单一风险因素。因此，了解调节衰老的生物分子和机制对于开发旨在最大限度提升老年人健康水平的干预措施至关重要。传统上，脂肪对寿命的影响被视为纯粹有害而被忽视。然而，新的研究开始揭示脂质作为信号分子对健康和寿命可能产生的有益影响。这些研究突显了衰老与脂质信号传导之间的复杂联系。在本综述中，我们总结了越来越多的证据，这些证据表明脂质代谢的变化，尤其是脂质信号传导，是健康衰老的潜在机制。
