Kim Yong-Dae, Yim Dong-Hyuk, Eom Sang-Yong, Yeoun Lee Ji, Kim Heon
Center for Farmers' Safety and Health, Chungbuk National University Hospital, Cheongju, Republic of Korea.
Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea.
J Biomed Res. 2017 Jul 13;31(4):344-349. doi: 10.7555/JBR.31.20160092.
Farmers are frequently exposed to ultraviolet (UV) radiation which causes various diseases by inducing oxidative stress. This study aimed to assess the effects of sunblock on oxidative stress in the body. Eighty-seven farmers were divided into two groups: those who wore sunblock for five days and those who did not. The total antioxidant capacity (TAC) in urine, which is an antioxidant indicator, and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels in urine, an oxidative stress indicator, were measured. The urinary TAC of sunblock users was significantly higher than that of non-users, but urinary 8-OHdG levels were not significantly different. Even after adjustment for potential confounders, urinary TAC was found to be markedly increased with sunblock usage. These results suggest that sunblock is effective in preventing oxidative stress among farmers. In addition, they show that urinary TAC can be used as a good effect marker of oxidative stress caused by UV exposure.
农民经常暴露于紫外线（UV）辐射下，这种辐射通过诱导氧化应激引发各种疾病。本研究旨在评估防晒霜对体内氧化应激的影响。87名农民被分为两组：一组连续五天使用防晒霜，另一组不使用。测量了作为抗氧化指标的尿中总抗氧化能力（TAC）以及作为氧化应激指标的尿中8-羟基-2-脱氧鸟苷（8-OHdG）水平。使用防晒霜者的尿TAC显著高于未使用者，但尿8-OHdG水平无显著差异。即使在对潜在混杂因素进行调整后，仍发现尿TAC随着防晒霜的使用而显著增加。这些结果表明，防晒霜对预防农民的氧化应激有效。此外，结果还表明尿TAC可作为紫外线暴露引起的氧化应激的良好效应标志物。
