The Effects of Erzincan Grape ( spp., ) and Benzothiazol on a Organism Model.

BACKGROUND

Grapes and their products are known to have been used for the treatment of diseases throughout history.

OBJECTIVE

It was aimed to investigate the effects of Erzincan Cimin grapes on an organism model of N2 wild type and BS913 strains with gonad cancer.

MATERIALS AND METHODS

The effects of methanol extracts of the skin and seeds of Erzincan Cimin grapes were examined separately on N2 wild type and an effect was determined on lifespan. By applying GS-MS analysis, a potential agent substance was determined in the skin and seed methanol extracts. This substance was purchased and the effects of this substance were investigated on lifespan and fertility in BS913 strains with gonad cancer. In addition, the effects on young subjects exposed to this agent substance in L1 form were investigated.

RESULTS

Grape seed and skin methanol extract was observed to prolong the lifespan most at a dose of 10 mg/100 mL. Lifespan was determined to be at a maximum in a gonad cancer organism model with benzothiazol at a dose of 50 ppm. At the same dose, positive effects were determined on the fertility of strains with cancer. When the effects of benzothiazol were examined on young L1 forms, an evident retardation of growth was determined at doses of 10, 50, and 100 ppm.

CONCLUSION

Owing to anti-carcinogenic effects of benzothiazol and benzothiazol-derived substances, they can be considered as agent substances in academic studies related to cancer.

SUMMARY

The effects of methanol extracts of the skin and seeds of Erzincan Cimin grapes were examined on N2 wild type and an effect was determined on lifespanThrough GS-MS analysis, benzothiazol was determined in the skin methanol extractsBenzothiazol was purchased and the effects of this substance were investigated on lifespan and fertility in BS913 strains with gonad cancerThe effects on young subjects exposed to benzothiazol in L1 formGrape seed, skin methanol extract, and benzothiazol was observed to prolong the lifespanPositive effects were determined on the fertility of gonad cancer strains. GC-MS: gas chromatography and mass spectrometry; : ; NGM: Nematode growth medium; : ; FUDR: Fluorodeoxyuridine; LDL: Low-density lipoprotein.