Catalina Mercedes, Cot Jaume, Borras Miquel, Lapuente Joaquín de, González Javier, Balu Alina M, Luque Rafael
Institute of Advanced Chemistry of Catalonia, IQAC, CSIC, C/Jordi Girona 18-26, Barcelona 08034, Spain.
Department of Organic Chemistry, University of Córdoba, Campus de Rabanales, Edif. Marie Curie, Ctra. Nnal IV-A, Km 396, Córdoba E14014, Spain.
Materials (Basel). 2013 Apr 29;6(5):1599-1607. doi: 10.3390/ma6051599.
The biomedical properties of a porous bio-collagenic polymer extracted from leather industrial waste residues have been investigated in wound healing and tissue regeneration in induced wounds in rats. Application of the pure undiluted bio-collagen to induced wounds in rats dramatically improved its healing after 7 days in terms of collagen production and wound filling as well as in the migration and differentiation of keratinocytes. The formulation tested was found to be three times more effective than the commercial reference product Catrix (Heal Progress (HP): 8 ± 1.55 2.33 ± 0.52, < 0.001; Formation of Collagen (FC): 7.5 ± 1.05 2.17 ± 0.75, < 0.001; Regeneration of Epidermis (RE): 13.33 ± 5.11 5 ± 5.48, < 0.05).
对从皮革工业废渣中提取的多孔生物胶原聚合物的生物医学特性进行了研究，观察其在大鼠创伤愈合和诱导伤口组织再生中的作用。将纯的未稀释生物胶原应用于大鼠诱导伤口，7天后，在胶原蛋白生成、伤口填充以及角质形成细胞的迁移和分化方面，伤口愈合情况显著改善。经测试，该配方的效果比市售参考产品Catrix高三倍（愈合进展（HP）：8±1.55对2.33±0.52，P<0.001；胶原蛋白形成（FC）：7.5±1.05对2.17±0.75，P<0.001；表皮再生（RE）：13.33±5.11对5±5.48，P<0.05）。
