Kirkpatrick D Lynn, Weiss Michelle, Naumov Anton, Bartholomeusz Geoffrey, Weisman R Bruce, Gliko Olga
Ensysce Biosciences Inc., 7000 Fannin St., Suite 2115, Houston, TX 77030, USA.
MD Anderson Cancer Center, 1901 East Road, Unit 1950, Houston, TX 77054, USA.
Materials (Basel). 2012 Feb 13;5(2):278-301. doi: 10.3390/ma5020278.
Carbon nanotubes have many unique physical and chemical properties that are being widely explored for potential applications in biomedicine especially as transporters of drugs, proteins, DNA and RNA into cells. Specifically, single-walled carbon nanotubes (SWCNT) have been shown to deliver siRNA to tumors in vivo. The low toxicity, the excellent membrane penetration ability, the protection afforded against blood breakdown of the siRNA payload and the good biological activity seen in vivo suggests that SWCNT may become universal transfection vehicles for siRNA and other RNAs for therapeutic applications. This paper will introduce a short review of a number of therapeutic applications for carbon nanotubes and provide recent data suggesting SWCNT are an excellent option for the delivery of siRNA clinically.
碳纳米管具有许多独特的物理和化学性质，这些性质正被广泛探索用于生物医学的潜在应用，特别是作为药物、蛋白质、DNA和RNA进入细胞的转运载体。具体而言，单壁碳纳米管（SWCNT）已被证明可在体内将小干扰RNA（siRNA）递送至肿瘤。其低毒性、出色的膜穿透能力、对siRNA有效载荷血液分解的保护作用以及在体内观察到的良好生物活性表明，SWCNT可能成为用于治疗应用的siRNA和其他RNA的通用转染载体。本文将简要综述碳纳米管的一些治疗应用，并提供近期数据表明SWCNT是临床上递送siRNA的极佳选择。
