Barthelmes Jens, Nägele Matthias P, Ludovici Valeria, Ruschitzka Frank, Sudano Isabella, Flammer Andreas J
University Hospital Zurich, University Heart Center, Raemistrasse 100, 8091 Zurich, Switzerland.
EPMA J. 2017 Jun 6;8(2):99-109. doi: 10.1007/s13167-017-0099-1. eCollection 2017 Jun.
The endothelium has increasingly been recognized as a smart barrier and a key regulator of blood flow in micro- and macrovascular beds. Endothelial dysfunction marks a stage of atherosclerosis and is an important prognostic marker for cardiovascular disease. Yet, some people who tend to be slim and physically active and with rather low blood pressure show a propensity to respond to certain stimuli such as emotional stress with endothelial-mediated vascular dysregulation (Flammer syndrome). This leads to characteristic vascular symptoms such as cold hands but also a risk for vascular-mediated diseases such as normal-tension glaucoma. It is the aim of this review to delineate the differences between Flammer syndrome and its "counterpart" endothelial dysfunction in the context of cardiovascular diseases.
内皮细胞越来越被认为是一种智能屏障，也是微血管和大血管床中血流的关键调节因子。内皮功能障碍标志着动脉粥样硬化的一个阶段，是心血管疾病的重要预后指标。然而，一些体型苗条、身体活跃且血压相当低的人在面对某些刺激（如情绪压力）时，容易出现内皮介导的血管调节异常（弗拉默综合征）。这会导致诸如手部冰冷等典型的血管症状，同时也会增加血管介导疾病（如正常眼压性青光眼）的风险。本综述的目的是在心血管疾病的背景下，阐述弗拉默综合征与其“对应物”内皮功能障碍之间的差异。
