Zhang Hai-Long, Li Jian-Sheng, Yu Xue-Qing, Li Su-Yun, Halmurat Upur, Xie Yang, Wang Yan-Fang, Li Feng-Sen, Wang Ming-Hang
Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Henan University of Traditional Chinese Medicine, Zhengzhou, People's Republic of China.
Department of Respiratory, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, People's Republic of China.
Int J Chron Obstruct Pulmon Dis. 2017 Aug 4;12:2333-2342. doi: 10.2147/COPD.S117461. eCollection 2017.
Pulmonary Daoyin (PD) (evolved from ancient Chinese daoyin skills), is a rehabilitation technology that combines specially designed movements of the arms and body and controlled breathing exercises, to improve the physiological and psychological status of patients with chronic respiratory disease. Pulmonary rehabilitation is effective for patients with chronic obstructive pulmonary disease (COPD), and the efficacy of PD is unknown. The aim of this study is to investigate the effect of a PD program in enhancing activity tolerance, patient-reported outcomes and satisfaction with the effectiveness on patients with COPD.
The multi-center, randomized controlled trial was conducted from November 2011 to June 2012 in local communities in cities of the 11 research centers in China. It included COPD patients (moderate to very severe) who were recruited from an outpatient clinic. A randomized controlled study included 464 COPD patients who were randomly allocated either to the PD group, participating in a 3-month, ten times-weekly supervised PD-based pulmonary rehabilitation program, or to a control group continuing with regular medical treatment alone. Data were gathered using the 6-minute walking distance (6MWD) test, COPD patient-reported outcomes (COPD-PRO) and Effectiveness Satisfaction Questionnaire for COPD (ESQ-COPD), which was filled out at baseline and 3 months post-intervention. SAS 9.2 was used for statistical analysis.
Of the 464 patients in the study, 461 were included in the full analysis set (FAS); 429 were in the per-protocol analysis set (PPS). After 3-month intervention, there was a significant difference between the two groups in 6MWD (FAS; =0.049; PPS; =0.041), total score and all domains of COPD-PRO (FAS; =0.014; PPS; =0.003) and ESQ-COPD (FAS; =0.038; PPS; <0.001).
The PD program was able to improve the activity tolerance level and satisfaction of COPD patients because of its effectiveness.
肺导引法（PD）（由中国古代导引术演变而来）是一种康复技术，它将专门设计的手臂和身体动作与有控制的呼吸练习相结合，以改善慢性呼吸道疾病患者的生理和心理状态。肺康复对慢性阻塞性肺疾病（COPD）患者有效，而肺导引法的疗效尚不清楚。本研究的目的是调查肺导引法方案对提高COPD患者活动耐量、患者报告结局以及对疗效的满意度的影响。
多中心随机对照试验于2011年11月至2012年6月在中国11个研究中心所在城市的当地社区进行。研究对象包括从门诊招募的COPD患者（中度至重度）。一项随机对照研究纳入了464例COPD患者，这些患者被随机分为两组，一组为肺导引法组，参与为期3个月、每周10次的基于肺导引法的监督性肺康复方案；另一组为对照组，仅继续接受常规药物治疗。在基线和干预后3个月时，使用6分钟步行距离（6MWD）测试、COPD患者报告结局（COPD-PRO）和COPD疗效满意度问卷（ESQ-COPD）收集数据。使用SAS 9.2进行统计分析。
在该研究的464例患者中，461例纳入全分析集（FAS）；429例纳入符合方案分析集（PPS）。经过3个月的干预，两组在6MWD（FAS；=0.049；PPS；=0.041）、COPD-PRO的总分及所有领域（FAS；=0.014；PPS；=0.003）和ESQ-COPD（FAS；=0.038；PPS；<0.001）方面存在显著差异。
肺导引法方案因其有效性能够提高COPD患者的活动耐量水平和满意度。
