Poznyak Anastasia V, Zhang Dongwei, Orekhova Varvara, Grechko Andrey V, Wetzker Reinhard, Orekhov Alexander N
Institute for Atherosclerosis Research, Skolkovo Innovative Center Moscow 121609, Russia.
Diabetes Research Center, Traditional Chinese Medicine School, Beijing University of Chinese Medicine Beijing 100029, China.
Am J Cardiovasc Dis. 2020 Jun 15;10(2):62-71. eCollection 2020.
Non-contagious diseases such as atherosclerosis, diabetes, cardiovascular disease, cancer, chronic respiratory diseases, and mental disorders hold responsibility for major health losses worldwide. Atherosclerosis was found to be the leading cause of deaths due to the major consequences, such as cardiovascular disease, stroke, ischemic heart disease, myocardial infarction, and others. The number of patients with atherosclerosis increases with every passing year. If treatment is not started on time, every second patient dies within 10 years. Moreover, the disease leads to persistent disability of patients, most of whom are of active working age. Atherosclerosis is a metabolic disorder characterized by hyperlipidemia and chronic inflammation. Although this disease annually kills a huge number of people, patients are now offered various therapeutic techniques, however, with different efficiencies. The scientific community is working to develop more effective means for treatment and precaution of the disease, regardless of the difficulties in understanding the causes of the health problem and the characteristics of its course. There are numerous strategies in the treatment and prevention of atherosclerosis, focusing on different aspects of the disease, such as inflammation, lipid metabolism alterations, or others, but none of them, unfortunately, is absolutely effective. In this review, we focused on the treatment approaches aimed at remedy the disruptions of lipid metabolism that are currently used in clinical practice.
动脉粥样硬化、糖尿病、心血管疾病、癌症、慢性呼吸道疾病和精神障碍等非传染性疾病是全球主要的健康损失原因。由于心血管疾病、中风、缺血性心脏病、心肌梗死等重大后果，动脉粥样硬化被发现是主要死因。动脉粥样硬化患者的数量逐年增加。如果不及时开始治疗，每两名患者中就有一人会在10年内死亡。此外，这种疾病会导致患者持续残疾，其中大多数处于工作年龄。动脉粥样硬化是一种以高脂血症和慢性炎症为特征的代谢紊乱疾病。尽管这种疾病每年导致大量人员死亡，但现在为患者提供了各种治疗技术，不过效率各不相同。科学界正在努力开发更有效的治疗和预防该疾病的方法，尽管在理解健康问题的原因及其病程特征方面存在困难。在动脉粥样硬化的治疗和预防方面有许多策略，侧重于该疾病的不同方面，如炎症、脂质代谢改变等，但不幸的是，没有一种策略是绝对有效的。在本综述中，我们重点关注了目前临床实践中用于纠正脂质代谢紊乱的治疗方法。
