Yamada Sumio, Kamiya Kuniyasu, Kono Yuji
Department of Rehabilitation Science, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Program in Physical and Occupational Therapy, Nagoya University Graduate School of Medicine, Nagoya, Japan.
ESC Heart Fail. 2015 Sep;2(3):168-170. doi: 10.1002/ehf2.12052. Epub 2015 Jul 28.
To examine the availability of frailty concept with objective criteria for risk stratification in patients with congestive heart failure (CHF).
Study design was secondary analysis of our CHF cohort. We selected 181 patients who completed clinical assessments and were successfully followed 2-year post discharge. To set frailty criteria, grip strength <26 kg in men and <17 kg in women (weakness) and performance measure for activities of daily living-8 ≧21 points (exhaustion) were defined for predicting 6 min walking distance <300 m (slowness) by the receiver-operating characteristics. During 2 years of follow up, subjects who met all the criteria had a 4 times greater risk of cardiac event compared with those with no frailty criteria.
The findings of present study suggest that frailty criteria may serve as a new clinical marker for management of patients with CHF.
探讨虚弱概念结合客观标准用于充血性心力衰竭（CHF）患者风险分层的可行性。
研究设计为对我们的CHF队列进行二次分析。我们选取了181例完成临床评估且出院后成功随访2年的患者。为设定虚弱标准，通过受试者工作特征曲线，将男性握力<26千克、女性握力<17千克（虚弱）以及日常生活活动能力量表-8得分≧21分（疲惫）定义为预测6分钟步行距离<300米（迟缓）的指标。在2年的随访期间，符合所有标准的受试者发生心脏事件的风险是无虚弱标准受试者的4倍。
本研究结果表明，虚弱标准可能作为CHF患者管理的一种新的临床标志物。
