Ciol Marcia Aparecida, Matsuda Patricia Noritake, Khurana Seema Rani, Cline Melissa Jaclyn, Sosnoff Jacob Jonathan, Kraft George Howard
Int J MS Care. 2017 Jul-Aug;19(4):217-224. doi: 10.7224/1537-2073.2016-120.
As disease progresses, cognitive demands may affect functional mobility in individuals with multiple sclerosis (MS). The Timed Up and Go (TUG) test assesses functional mobilityin populationssuch as MS. A cognitive-demanding task can be added to the TUG test to assess its effect on functional mobility.
People with MS (n = 52) and controls (n = 57) performed three versions of the TUG test: TUG alone (TUG-alone), TUG plus reciting the alphabet (TUG-alpha), and TUG plus subtracting numbers by 3s (TUG-3s). Times to complete the TUG tests were compared among controls and three groups of participants with MS created using Expanded Disability Status Scale (EDSS) scores 0 to 3.5, 4.0 to 5.5, and 6. Differences among groups were analyzed using split-plot analysis of variance.
Group and TUG type were significant (P < .001 for both), with no interaction effect of group × TUG type (P = .21). Mean times were 8.7, 9.4, and 11.1 seconds to perform the TUG-alone, TUG-alpha, and TUG-3s, respectively. Mean times for groups were 8.0, 8.2, 11.1, and 11.6 seconds for controls and individuals with MS and EDSS 0 to 3.5, 4.0 to 5.5, and 6, respectively.
People with MS with an EDSS score greater than 3.5 had a statistically significant reduction in performance of the TUG test even with the addition of a simple cognitive task, which might have implications for a person's more complex everyday activities.
随着疾病进展，认知需求可能会影响多发性硬化症（MS）患者的功能性移动能力。定时起立行走（TUG）测试用于评估MS等人群的功能性移动能力。可以在TUG测试中添加一项需要认知的任务，以评估其对功能性移动能力的影响。
MS患者（n = 52）和对照组（n = 57）进行了三种版本的TUG测试：单独的TUG测试（TUG-alone）、TUG测试加上背诵字母表（TUG-alpha）以及TUG测试加上每次减3的减法运算（TUG-3s）。比较了对照组以及根据扩展残疾状态量表（EDSS）评分分为0至3.5、4.0至5.5和6的三组MS患者完成TUG测试的时间。使用裂区方差分析来分析组间差异。
组和TUG测试类型均具有显著性（两者P <.001），组×TUG测试类型无交互作用（P = 0.21）。执行TUG-alone、TUG-alpha和TUG-3s的平均时间分别为8.7秒、9.4秒和11.1秒。对照组以及EDSS评分为0至3.5、4.0至5.5和6的MS患者组的平均时间分别为8.0秒、8.2秒、11.1秒和11.6秒。
即使添加了简单的认知任务，EDSS评分大于3.5的MS患者在TUG测试中的表现仍有统计学意义的下降，这可能会对一个人更复杂的日常活动产生影响。
