State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100101, China.
Zhejiang Provincial (Wenzhou) Key Lab for Water Environment and Marine Biological Resources Protection, College of Life and Environmental Science, Wenzhou University , Wenzhou 325035, China.
Org Lett. 2017 Sep 1;19(17):4700-4703. doi: 10.1021/acs.orglett.7b02346. Epub 2017 Aug 24.
By deleting the COP9 signalosome subunit PfcsnE from Pestalotiopsis fici, seven compounds that were newly produced by the mutant could be characterized, including five new structures, pestaloficins A-E (1 and 3-6). Pestaloficin A (1) represents a new type of dimeric cyclohexanone derivative linked through an unprecedented pentacyclic spiral ring.
通过删除 Pestalotiopsis fici 中的 COP9 信号osome 亚基 PfcsnE，从突变体中可以鉴定出七种新产生的化合物，包括五种新结构，即 pestaloficins A-E（1 和 3-6）。Pestaloficin A（1）代表了一种新型的通过前所未有的五环螺旋环连接的二聚环己酮衍生物。
