Wang Zhiyou, Yuan Daixiu, Duan Yehui, Li Shujuan, Hou Shengzhen
State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, 810016, Qinghai, China.
Department of Medicine, Jishou University, Jishou, 41600, Hunan, China.
Eat Weight Disord. 2018 Jun;23(3):267-274. doi: 10.1007/s40519-017-0428-3. Epub 2017 Aug 24.
Obesity has been considered to be a chronic disease that requires medical prevention and treatment. Intriguingly, many factors, including adipose tissue dysfunction, mitochondrial dysfunction, alterations in the muscle fiber phenotype and in the gut microbiota composition, have been identified to be involved in the development of obesity and its associated metabolic disorders (in particular type 2 diabetes mellitus). In this narrative review, we will discuss our current understanding of the relationships of these factors and obesity development, and provide a summary of potential treatments to manage obesity. Level of Evidence Level V, narrative review.
肥胖已被视为一种需要医学预防和治疗的慢性疾病。有趣的是，许多因素，包括脂肪组织功能障碍、线粒体功能障碍、肌纤维表型改变和肠道微生物群组成变化，已被确定与肥胖及其相关代谢紊乱（尤其是2型糖尿病）的发生有关。在这篇叙述性综述中，我们将讨论目前对这些因素与肥胖发生之间关系的理解，并总结管理肥胖的潜在治疗方法。证据级别：V级，叙述性综述。
