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技术:是否有足够的证据来改变凝血功能障碍床旁管理的实践?

Technology: Is There Sufficient Evidence to Change Practice in Point-of-Care Management of Coagulopathy?

作者信息

Fabbro Michael, Winkler Anne M, Levy Jerrold H

机构信息

Miller School of Medicine, University of Miami, Miami, FL.

Instrumentation Laboratory, Bedford, MA.

出版信息

J Cardiothorac Vasc Anesth. 2017 Oct;31(5):1849-1856. doi: 10.1053/j.jvca.2017.05.037. Epub 2017 May 19.

Abstract

Currently, hemostasis is one of the most widely researched topics in perioperative medicine. As investigators learn more about the complexity of coagulation, developing tests with the ability to rapidly monitor coagulation and guide targeted therapy is the key to optimizing hemostasis management. There is mounting evidence that algorithmic transfusion using point-of-care (POC) testing can reduce red cell and platelet transfusions and major bleeding after cardiac surgery. Integrating these tests during cardiac surgery and trauma management is especially important because these groups use the most blood products within a health system and the risks of transfusion are well documented. Currently, numerous POC tests are available for evaluating hemostasis. The purpose of this review is to provide a comprehensive evaluation of the current evidence surrounding the most common POC testing devices in practice for managing coagulation.

摘要

目前,止血是围手术期医学中研究最为广泛的课题之一。随着研究人员对凝血复杂性的了解不断深入,开发能够快速监测凝血并指导靶向治疗的检测方法是优化止血管理的关键。越来越多的证据表明,使用床旁检测(POC)进行算法输血可减少心脏手术后的红细胞和血小板输注以及大出血情况。在心脏手术和创伤管理过程中整合这些检测尤为重要,因为这些人群在医疗系统中使用的血液制品最多,且输血风险已有充分记录。目前,有许多床旁检测可用于评估止血情况。本综述的目的是对目前实践中用于管理凝血的最常见床旁检测设备的现有证据进行全面评估。

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