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32000道尔顿肺表面活性物质相关蛋白A的编码序列位于第10号染色体上，并确定了两种不同的限制性片段长度多态性。

The coding sequence for the 32,000-dalton pulmonary surfactant-associated protein A is located on chromosome 10 and identifies two separate restriction-fragment-length polymorphisms.

作者信息

Fisher J H, Kao F T, Jones C, White R T, Benson B J, Mason R J

出版信息

Am J Hum Genet. 1987 Jun;40(6):503-11.

PMID:2884868
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1684155/
Abstract

The primary protein component of human pulmonary surfactant is a 32,000-dalton glycoprotein called surfactant-associated protein A. This protein is important for normal lung function, and its expression is developmentally regulated. Using a mapping panel of somatic-cell hybrids, we have localized the coding sequence for pulmonary surfactant-associated protein A to chromosome 10. Additionally, this sequence identifies two separate MspI restriction-fragment-length polymorphisms. Since there is a relative lack of polymorphic markers for chromosome 10, this sequence may be useful in linkage analysis.

摘要

人肺表面活性物质的主要蛋白质成分是一种名为表面活性物质相关蛋白A的32000道尔顿糖蛋白。这种蛋白质对正常肺功能很重要，其表达受发育调控。利用体细胞杂种定位板，我们已将肺表面活性物质相关蛋白A的编码序列定位到10号染色体。此外，该序列鉴定出两个独立的MspI限制性片段长度多态性。由于10号染色体相对缺乏多态性标记，该序列可能在连锁分析中有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8288/1684155/10de36a8ead4/ajhg00142-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8288/1684155/22cd30ce7b27/ajhg00142-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8288/1684155/10de36a8ead4/ajhg00142-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8288/1684155/22cd30ce7b27/ajhg00142-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8288/1684155/10de36a8ead4/ajhg00142-0035-a.jpg

相似文献

1
The coding sequence for the 32,000-dalton pulmonary surfactant-associated protein A is located on chromosome 10 and identifies two separate restriction-fragment-length polymorphisms.32000道尔顿肺表面活性物质相关蛋白A的编码序列位于第10号染色体上，并确定了两种不同的限制性片段长度多态性。
Am J Hum Genet. 1987 Jun;40(6):503-11.
2
The coding sequence for the human 18,000-dalton hydrophobic pulmonary surfactant protein is located on chromosome 2 and identifies a restriction fragment length polymorphism.人类18000道尔顿疏水肺表面活性蛋白的编码序列位于2号染色体上，并确定了一种限制性片段长度多态性。
Somat Cell Mol Genet. 1988 Jan;14(1):105-10. doi: 10.1007/BF01535054.
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The 35 kd pulmonary surfactant-associated protein is encoded on chromosome 10.35千道尔顿的肺表面活性物质相关蛋白由10号染色体编码。
Hum Genet. 1987 May;76(1):58-62. doi: 10.1007/BF00283051.
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The gene encoding the hydrophobic surfactant protein SP-C is located on 8p and identifies an EcoRI RFLP.编码疏水性表面活性蛋白SP-C的基因位于8号染色体短臂，并可识别一种EcoRI限制性片段长度多态性。
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Assignment of the human pulmonary surfactant protein D gene (SFTP4) to 10q22-q23 close to the surfactant protein A gene cluster.人类肺表面活性物质蛋白D基因（SFTP4）定位于10q22 - q23，靠近表面活性物质蛋白A基因簇。
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Cytogenet Cell Genet. 1995;68(1-2):8-10. doi: 10.1159/000133878.
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Regional localization of polymorphic markers on chromosome 10 by physical and genetic mapping.通过物理图谱和遗传图谱对10号染色体上多态性标记进行区域定位。
Ann Hum Genet. 1990 May;54(2):121-9. doi: 10.1111/j.1469-1809.1990.tb00368.x.
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Human surfactant protein--A gene locus for genetic studies in the Finnish population.人表面活性蛋白A基因座：芬兰人群中的遗传学研究对象
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Dinucleotide repeat polymorphism in the human surfactant-associated protein 3 gene (SFTP3).人类表面活性物质相关蛋白3基因（SFTP3）中的二核苷酸重复多态性。
Nucleic Acids Res. 1991 Jul 11;19(13):3756.
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Four restriction fragment length polymorphisms revealed by probes from a single cosmid map to chromosome 19.来自单个黏粒图谱的探针在19号染色体上揭示了四种限制性片段长度多态性。
Am J Hum Genet. 1986 Apr;38(4):447-60.

引用本文的文献

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BMC Med Genet. 2007 Apr 2;8:15. doi: 10.1186/1471-2350-8-15.
2
Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma.表面活性蛋白A基因多态性与哮喘高危婴儿中耳炎的相关性
BMC Med Genet. 2006 Aug 2;7:68. doi: 10.1186/1471-2350-7-68.
3
Bench-to-bedside review: Paediatric viral lower respiratory tract disease necessitating mechanical ventilation--should we use exogenous surfactant?

本文引用的文献

1
Isolation and chromosomal localization of unique DNA sequences from a human genomic library.从人类基因组文库中分离独特DNA序列并进行染色体定位。
Proc Natl Acad Sci U S A. 1982 Feb;79(3):865-9. doi: 10.1073/pnas.79.3.865.
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Immunocytochemical localization and identification of the major surfactant protein in adult rat lung.成年大鼠肺中主要表面活性物质蛋白的免疫细胞化学定位与鉴定
J Histochem Cytochem. 1981 Feb;29(2):291-305. doi: 10.1177/29.2.7019304.
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Evidence of lung surfactant abnormality in respiratory failure. Study of bronchoalveolar lavage phospholipids, surface activity, phospholipase activity, and plasma myoinositol.
从实验台到病床的综述：需要机械通气的小儿病毒性下呼吸道疾病——我们应该使用外源性表面活性剂吗？
Crit Care. 2005;9(6):550-5. doi: 10.1186/cc3823. Epub 2005 Oct 5.
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Association between the surfactant protein A (SP-A) gene locus and respiratory-distress syndrome in the Finnish population.芬兰人群中表面活性蛋白A（SP-A）基因位点与呼吸窘迫综合征之间的关联。
Am J Hum Genet. 2000 May;66(5):1569-79. doi: 10.1086/302906. Epub 2000 Apr 4.
5
Construction of radiation-reduced hybrids and their use in mapping of microclones from chromosome 10p11.2-q11.2.低辐射杂种的构建及其在10号染色体p11.2-q11.2微克隆图谱绘制中的应用。
Jpn J Hum Genet. 1993 Dec;38(4):361-70. doi: 10.1007/BF01907982.
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Phylogenetic conservation and physical mapping of members of the H6 homeobox gene family.H6 同源框基因家族成员的系统发育保守性与物理图谱分析
Mamm Genome. 1995 Jun;6(6):383-8. doi: 10.1007/BF00355637.
7
The gene encoding the hydrophobic surfactant protein SP-C is located on 8p and identifies an EcoRI RFLP.编码疏水性表面活性蛋白SP-C的基因位于8号染色体短臂，并可识别一种EcoRI限制性片段长度多态性。
Am J Hum Genet. 1988 Oct;43(4):436-41.
8
Function and regulation of expression of pulmonary surfactant-associated proteins.肺表面活性物质相关蛋白的功能及表达调控
Biochem J. 1991 Jan 15;273(Pt 2)(Pt 2):249-64. doi: 10.1042/bj2730249.
9
Mouse chromosome 14.小鼠14号染色体。
Mamm Genome. 1992;3 Spec No:S206-19. doi: 10.1007/BF00648432.
10
Chromosomal assignment and linkage analysis of the human glutathione S-transferase mu gene (GSTM1) using intron specific polymerase chain reaction.利用内含子特异性聚合酶链反应对人类谷胱甘肽S-转移酶μ基因（GSTM1）进行染色体定位和连锁分析。
Hum Genet. 1992 Dec;90(4):435-9. doi: 10.1007/BF00220473.
呼吸衰竭中肺表面活性物质异常的证据。支气管肺泡灌洗磷脂、表面活性、磷脂酶活性及血浆肌醇的研究。
J Clin Invest. 1982 Sep;70(3):673-83. doi: 10.1172/jci110662.
4
Characterization of rabbit surfactant-associated proteins.兔表面活性物质相关蛋白的特性分析
Biochim Biophys Acta. 1983 Nov 29;754(2):218-26. doi: 10.1016/0005-2760(83)90164-9.
5
An electrophoretic and immunochemical characterization of human surfactant-associated proteins.人表面活性物质相关蛋白的电泳及免疫化学特性分析
Biochim Biophys Acta. 1984 Dec 7;791(2):226-38. doi: 10.1016/0167-4838(84)90013-x.
6
Analysis of pulmonary surfactant apoproteins by isoelectric focusing.通过等电聚焦分析肺表面活性物质载脂蛋白。
Biochim Biophys Acta. 1984 Jul 26;794(3):411-8. doi: 10.1016/0005-2760(84)90007-9.
7
Localization of the structural gene for human apolipoprotein A-I on the long arm of human chromosome 11.人类载脂蛋白A-I结构基因在人类第11号染色体长臂上的定位。
Proc Natl Acad Sci U S A. 1984 Jan;81(2):508-11. doi: 10.1073/pnas.81.2.508.
8
Isolation of a major apolipoprotein of canine and murine pulmonary surfactant. Biochemical and immunochemical characteristics.犬和鼠肺表面活性物质主要载脂蛋白的分离。生化和免疫化学特性。
Biochim Biophys Acta. 1981 Sep 24;665(3):442-53. doi: 10.1016/0005-2760(81)90257-5.
9
Wilms' tumor-aniridia association: segregation of affected chromosome in somatic cell hybrids, identification of cell surface antigen associated with deleted area, and regional mapping of c-Ha-ras-1 oncogene, insulin gene, and beta-globin gene.威尔姆斯瘤-无虹膜综合征：体细胞杂种中受累染色体的分离、与缺失区域相关的细胞表面抗原的鉴定以及c-Ha-ras-1癌基因、胰岛素基因和β-珠蛋白基因的区域定位。
Somat Cell Mol Genet. 1984 Sep;10(5):455-64. doi: 10.1007/BF01534850.
10
Genetic mapping of the structural gene for antithrombin III to human chromosome 1.抗凝血酶III结构基因在人类1号染色体上的基因定位。
Hum Genet. 1984;67(1):34-6. doi: 10.1007/BF00270555.