Department of Rehabilitation, Physical and Sports Medicine, Institute of Health Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania; Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Am J Med. 2018 Feb;131(2):148-155. doi: 10.1016/j.amjmed.2017.07.038. Epub 2017 Aug 31.
Metabolic syndrome, physical inactivity, and central obesity contribute to early vascular aging, which leads to increased risk of cardiovascular disease. This study aimed to assess the effect of heart rate (HR)-targeted aerobic exercise training on the indices of early vascular aging, in particular, arterial stiffness, and on anthropometric and clinical profile of metabolic syndrome subjects.
There were 126 metabolic syndrome subjects randomly selected. Anthropometric parameters, blood pressure (BP), blood sample, and arterial wall functional and structural parameters were obtained prior to and after the 8-week (84 patients) supervised training program. The age- and sex-matched control group (42 patients) followed the same protocol, except for the HR-targeted training program.
In the study group, HR-targeted training was associated with decreased aortic pulse wave velocity (8.47 ± 1.40 vs 8.01 ± 1.06 m/s; P = .005), HR (P < .001), systolic (P < .015) and diastolic (P < .004) BP, waist circumference (P < .004), total and low-density-lipid cholesterol (respectively, 6.42 ± 1.41 vs 5.89 ± 1.32, P = .003 and 4.2 ± 1.18 vs 3.8 ± 1.21, P = .002), and an increase in aerobic capacity (P < .001). In the control group there were no statistically significant changes of arterial stiffness parameters. Multivariate analysis revealed that reduction of arterial stiffness was BP dependent.
In subjects with metabolic syndrome, HR-targeted exercise training is associated with BP-dependent decrease in aortic stiffness and improvement of metabolic and fitness parameters.
代谢综合征、身体活动不足和中心性肥胖会导致早期血管老化，从而增加心血管疾病的风险。本研究旨在评估心率（HR）靶向有氧运动训练对早期血管老化指标的影响，特别是动脉僵硬度，以及对代谢综合征患者的人体测量和临床特征的影响。
随机选择了 126 名代谢综合征患者。在 8 周（84 名患者）的监督训练计划之前和之后，获得了人体测量参数、血压（BP）、血液样本以及动脉壁功能和结构参数。年龄和性别匹配的对照组（42 名患者）遵循相同的方案，但不进行 HR 靶向训练计划。
在研究组中，HR 靶向训练与主动脉脉搏波速度（PWV）降低相关（8.47±1.40 对 8.01±1.06 m/s；P=0.005），HR（P<0.001）、收缩压（P<0.015）和舒张压（P<0.004）、腰围（P<0.004）、总胆固醇和低密度脂蛋白胆固醇（分别为 6.42±1.41 对 5.89±1.32，P=0.003 和 4.2±1.18 对 3.8±1.21，P=0.002）以及有氧能力增加（P<0.001）。在对照组中，动脉僵硬度参数没有统计学上的显著变化。多变量分析显示，动脉僵硬度的降低与血压有关。
在代谢综合征患者中，HR 靶向运动训练与血压依赖性降低主动脉僵硬度以及改善代谢和适应能力参数有关。
