Wang Qi, Chao Yi-Min
School of Medicine, University of East Anglia, Norwich Research Park, Norwich NR4 7UQ, UK.
School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7UQ, UK.
J Biomed Res. 2018 Mar 26;32(2):91-106. doi: 10.7555/JBR.31.20160146.
Incorporating both diagnostic and therapeutic functions into a single nanoscale system is an effective modern drug delivery strategy. Combining liposomes with semiconductor quantum dots (QDs) has great potential to achieve such dual functions, referred to in this review as a liposomal QD hybrid system (L-QD). Here we review the recent literature dealing with the design and application of L-QD for advances in bio-imaging and drug delivery. After a summary of L-QD synthesis processes and evaluation of their properties, we will focus on their multifunctional applications, ranging from cell imaging to theranostic drug delivery approaches.
将诊断和治疗功能整合到单个纳米级系统中是一种有效的现代药物递送策略。将脂质体与半导体量子点（QD）相结合具有实现这种双重功能的巨大潜力，在本综述中称为脂质体量子点混合系统（L-QD）。在此，我们综述了近期关于L-QD在生物成像和药物递送方面进展的设计与应用的文献。在总结L-QD的合成过程及其性能评估之后，我们将重点关注其多功能应用，从细胞成像到治疗诊断药物递送方法。
