The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Adv Mater. 2017 Oct;29(40). doi: 10.1002/adma.201703702. Epub 2017 Sep 5.
A smart release system responsive to near-infrared (NIR) light is developed for intracellular drug delivery. The concept is demonstrated by coencapsulating doxorubicin (DOX) (an anticancer drug) and IR780 iodide (IR780) (an NIR-absorbing dye) into nanoparticles made of a eutectic mixture of naturally occurring fatty acids. The eutectic mixture has a well-defined melting point at 39 °C, and can be used as a biocompatible phase-change material for NIR-triggered drug release. The resultant nanoparticles exhibit prominent photothermal effect and quick drug release in response to NIR irradiation. Fluorescence microscopy analysis indicates that the DOX trapped in the nanoparticles can be efficiently released into the cytosol under NIR irradiation, resulting in enhanced anticancer activity. A new platform is thus offered for designing effective intracellular drug-release systems, holding great promise for future cancer therapy.
一种对近红外光（NIR）响应的智能释放系统被开发用于细胞内药物输送。该概念通过将阿霉素（DOX）（一种抗癌药物）和 IR780 碘化物（IR780）（一种 NIR 吸收染料）共包封到由天然存在的脂肪酸的共晶混合物制成的纳米颗粒中得到证明。共晶混合物在 39°C 具有明确的熔点，可用作 NIR 触发药物释放的生物相容的相变型材料。所得的纳米颗粒表现出显著的光热效应，并在响应 NIR 照射时快速释放药物。荧光显微镜分析表明，在 NIR 照射下，被困在纳米颗粒中的 DOX 可以有效地释放到细胞质中，从而增强抗癌活性。因此，为设计有效的细胞内药物释放系统提供了一个新平台，为未来的癌症治疗带来了巨大的希望。
