Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy; Macrofarm s.r.l., c/o Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, 87036 Rende, CS, Italy.
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy.
Curr Opin Pharmacol. 2017 Oct;36:72-77. doi: 10.1016/j.coph.2017.08.004. Epub 2017 Sep 8.
Diseases related to bacterial infections represent a relevant challenge for public health. Despite the success obtained with the conventional antibiotic therapies, indeed, new drawbacks have been identified. In addition to poor drugs solubility and stability, adverse side effects, and many other factors which together lead to a low patient compliance, the antibiotic resistance and the lack in the development of new antimicrobial agents are the main problems. On the basis of these considerations, the research interest is focused on the exploration of new strategies able to circumvent these drawbacks improving the efficacy of current antibiotics. In this context, nanosized systems, which allow to enhance both the pharmacokinetic profiles and the mechanism of action of drugs, play a key role.
与细菌感染相关的疾病是公共卫生的一个重大挑战。尽管传统抗生素疗法取得了成功，但确实也出现了一些新的问题。除了药物溶解度和稳定性差、不良反应等因素导致患者的依从性低外，抗生素耐药性和新抗菌药物研发的缺乏也是主要问题。基于这些考虑，研究重点集中在探索新的策略，以克服这些缺陷，提高现有抗生素的疗效。在这种情况下，纳米系统在增强药物的药代动力学特征和作用机制方面发挥着关键作用。
