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新鲜制备的臭氧水和洗必泰用作口腔含漱液时的抗菌活性——一项随机临床研究

Antibacterial Activity of Freshly Prepared Ozonated Water and Chlorhexidine on When Used as an Oral Rinse - A Randomised Clinical Study.

作者信息

Anumula Lavanya, Kumar Kv Suneel, Krishna Chnv Murali, Lakshmi K Sree

机构信息

Professor, Department of Conservative Dentistry and Endodontics, Narayana Dental College, Nellore, Andhra Pradesh, India.

Reader, Department of Oral Medicine and Radiology, Narayana Dental College, Nellore, Andhra Pradesh, India.

出版信息

J Clin Diagn Res. 2017 Jul;11(7):ZC05-ZC08. doi: 10.7860/JCDR/2017/26708.10129. Epub 2017 Jul 1.

Abstract

INTRODUCTION

Dental caries is one of the most common causes of morbidity of the tooth. Attempts have been made to reduce the pathogen population size i.e., (MS) to demote the incidence of caries and increase the resistance of the tooth to cariogenic attack.

AIM

To evaluate the antibacterial efficacy of freshly prepared ozonated water, in proposing it as an alternative mouth rinse on MS in comparison to Chlorhexidine (CHX).

MATERIALS AND METHODS

Subjects with high caries incidence and MS counts more than 105 Colony Forming Unit (CFU) were selected and divided by block randomization into two groups of 23 subjects each. The subjects were advised to use the respective mouth rinses under the operator surveillance, consecutively for 14 days. Stimulated salivary samples were collected from the subjects on the first day, 7 and 14 day to analyse the changes in MS counts during the course of use of oral rinses. The obtained data was tabulated and statistically analysed.

RESULTS

Freshly prepared ozonated water showed a statistically significant reduction in MS counts after an interval of 7 days and 14 days when compared to CHX.

CONCLUSION

Ozonated water when consecutively used as a mouth rinse resulted in a significant reduction of MS counts. Hence, it can be used as an alternative to chlorhexidine.

摘要

引言

龋齿是牙齿发病最常见的原因之一。人们已尝试减少病原菌数量,即变形链球菌(MS),以降低龋齿发病率并增强牙齿对致龋攻击的抵抗力。

目的

评估新制备的臭氧水的抗菌效果,将其作为与氯己定(CHX)相比的替代漱口水用于对抗变形链球菌。

材料与方法

选择龋齿发病率高且变形链球菌计数超过105菌落形成单位(CFU)的受试者,通过区组随机化分为两组,每组23名受试者。建议受试者在操作人员监督下连续14天使用各自的漱口水。在第1天、第7天和第14天从受试者收集刺激唾液样本,以分析使用漱口水过程中变形链球菌计数的变化。将获得的数据制成表格并进行统计分析。

结果

与氯己定相比,新制备的臭氧水在7天和14天后变形链球菌计数显示出统计学上的显著降低。

结论

连续用作漱口水时,臭氧水可显著降低变形链球菌计数。因此,它可作为氯己定的替代品。

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