细菌外毒素和内毒素对粒细胞功能的调节
Modulation of granulocyte functions by bacterial exotoxin and endotoxins.
作者信息
Bremm K D, König W, Thelestam M, Alouf J E
机构信息
Lehrstuhl für Medizinische Mikrobiologie und Immunologie, AG Infektabwehr, Ruhr-Universität Bochum, West Germany.
出版信息
Immunology. 1987 Nov;62(3):363-71.
Abstract
The modulation of granulocyte functions by bacterial exotoxins (Streptolysin O, alveolysin, theta toxin) and endotoxins from salmonella and lipid A is described here. Incubation of polymorphonuclear granulocytes with thiol-activated toxins resulted in an increased leukotriene generation. Toxin-pretreated PMNs revealed an increased omega oxidation of LTB4, which may explain why toxin-stimulated cells release more LTC4 than LTB4. Furthermore, toxin-pretreated PMNs showed a decreased leukotriene generation on subsequent stimulation with the Ca-ionophore A 23187 or opsonized zymosan.
摘要
本文描述了细菌外毒素（链球菌溶血素O、肺泡溶血素、θ毒素）以及沙门氏菌内毒素和脂质A对粒细胞功能的调节作用。用硫醇激活毒素孵育多形核粒细胞会导致白三烯生成增加。经毒素预处理的多形核白细胞显示白三烯B4的ω氧化增加，这可能解释了为何毒素刺激的细胞释放的白三烯C4比白三烯B4更多。此外，经毒素预处理的多形核白细胞在随后用钙离子载体A 23187或调理酵母聚糖刺激时，白三烯生成减少。
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本文引用的文献
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Effect of staphylococcal alpha-toxin on phagocytosis of staphylococci by human polymorphonuclear leukocytes.葡萄球菌α毒素对人多形核白细胞吞噬葡萄球菌的影响。
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Effect of Escherichia coli alpha-hemolysin on human peripheral leukocyte function in vitro.大肠杆菌α-溶血素对人外周血白细胞体外功能的影响。
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Interaction of radiolabeled endotoxin molecules with human monocyte membranes.放射性标记的内毒素分子与人类单核细胞膜的相互作用。
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Surface properties of bacterial sulfhydryl-activated cytolytic toxins. Interaction with monomolecular films of phosphatidylcholine and various sterols.细菌巯基激活细胞溶解毒素的表面特性。与磷脂酰胆碱和各种固醇单分子膜的相互作用。
Eur J Biochem. 1984 May 15;141(1):205-10. doi: 10.1111/j.1432-1033.1984.tb08176.x.
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