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GPR133 Promotes Glioblastoma Growth in Hypoxia.

作者信息

Frenster Joshua D, Inocencio Julio F, Xu Zhongye, Dhaliwal Joravar, Alghamdi Abdulhakeem, Zagzag David, Bayin N Sumru, Placantonakis Dimitris G

机构信息

Department of Neurosurgery, NYU School of Medicine, New York, New York.

Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, New York.

出版信息

Neurosurgery. 2017 Sep 1;64(CN_suppl_1):177-181. doi: 10.1093/neuros/nyx227.

Abstract
摘要

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GPR133 (ADGRD1), an adhesion G-protein-coupled receptor, is necessary for glioblastoma growth.
Oncogenesis. 2016 Oct 24;5(10):e263. doi: 10.1038/oncsis.2016.63.
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Mol Pharmacol. 2015 Sep;88(3):617-23. doi: 10.1124/mol.115.098749. Epub 2015 May 8.
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Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells.
Nat Commun. 2015 Apr 2;6:6411. doi: 10.1038/ncomms7411.
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Selective lentiviral gene delivery to CD133-expressing human glioblastoma stem cells.
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A tethered agonist within the ectodomain activates the adhesion G protein-coupled receptors GPR126 and GPR133.
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