Noseda A, Peeters T L, Delhaye M, Bormans V, Couvreur Y, Vandermoten G, de Francquen P, Rocmans P, Yernault J C
Chest Department, Hôpital Erasme, Brussels, Belgium.
Thorax. 1987 Oct;42(10):784-9. doi: 10.1136/thx.42.10.784.
Plasma samples from 21 patients with small cell carcinoma of the lung were screened for pancreatic polypeptide, somatostatin, motilin, and vasoactive intestinal polypeptide. One patient had severe impairment of both renal and liver function. In the 20 remaining subjects vasoactive intestinal polypeptide concentrations were normal, and only two patients had increased concentrations of somatostatin. Increases in pancreatic polypeptide were detected more commonly (7/20), but these may have been non-specific age related increases. The major finding was high concentrations of motilin (greater than 496 pg/ml) in 17 of 20 patients. Plasma motilin was subsequently assayed in 16 more patients with lung cancer, including 10 patients with non-small cell carcinoma of the lung. At concentrations over 900 pg/ml plasma motilin appears to be a tumour marker for small cell carcinoma of the lung with acceptable sensitivity (59%) and specificity (78%). The origin of increased plasma motilin in small cell carcinoma of the lung was investigated. Bombesin (gastrin releasing peptide), a peptide known to stimulate the release of motilin in man, was, as in previous studies, detected in tumour but not in plasma, except in one patient out of 21. Immunohistochemical studies failed to detect motilin antigen in biopsy samples. Motilin tumour content was found to be low in tumour tissue from three patients with small cell carcinoma of the lung who had appreciable hypermotilinaemia and from three patients with non-small cell carcinoma of the lung who had either normal or slightly raised plasma motilin concentrations. The stimulus to motilin secretion in patients with small cell carcinoma of the lung remains unclear.
对21例肺小细胞癌患者的血浆样本进行了胰多肽、生长抑素、胃动素和血管活性肠肽的筛查。1例患者有严重的肾功能和肝功能损害。在其余20名受试者中，血管活性肠肽浓度正常，只有2例患者的生长抑素浓度升高。胰多肽升高的情况更常见（7/20），但这些可能是非特异性的与年龄相关的升高。主要发现是20例患者中有17例胃动素浓度高（大于496 pg/ml）。随后对另外16例肺癌患者进行了血浆胃动素检测，其中包括10例肺非小细胞癌患者。血浆胃动素浓度超过900 pg/ml似乎是肺小细胞癌的一种肿瘤标志物，其敏感性（59%）和特异性（78%）可以接受。对肺小细胞癌患者血浆胃动素升高的来源进行了研究。蛙皮素（胃泌素释放肽）是一种已知能刺激人体释放胃动素的肽，与之前的研究一样，在肿瘤中检测到了蛙皮素，但在血浆中未检测到，21例患者中只有1例除外。免疫组织化学研究未能在活检样本中检测到胃动素抗原。在3例有明显高胃动素血症的肺小细胞癌患者和3例血浆胃动素浓度正常或略有升高的肺非小细胞癌患者的肿瘤组织中，发现胃动素肿瘤含量较低。肺小细胞癌患者胃动素分泌的刺激因素仍不清楚。
