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慢性疼痛接受医用大麻治疗的成年人中与睡眠相关问题的流行率和相关因素。

Prevalence and correlates of sleep-related problems in adults receiving medical cannabis for chronic pain.

机构信息

Department of Psychiatry, University of Michigan, Rachel Upjohn Building, 4250 Plymouth Road, Ann Arbor, MI, 48109-2700, United States.

Department of Psychiatry, University of Michigan, Rachel Upjohn Building, 4250 Plymouth Road, Ann Arbor, MI, 48109-2700, United States.

出版信息

Drug Alcohol Depend. 2017 Nov 1;180:227-233. doi: 10.1016/j.drugalcdep.2017.08.017. Epub 2017 Sep 9.

Abstract

PURPOSE

To examine the prevalence and correlates of sleep problems in a sample of medical cannabis patients.

PROCEDURES

Adults ages 21 and older (N=801,M age=45.8) who were seeking medical cannabis certification (either for the first time or as a renewal) for chronic pain at medical cannabis clinics in southern Michigan completed baseline measures of cannabis use, sleep, pain, and other related constructs.

FINDINGS

Over half of the sample (59%) met criteria for past 1-month sleep disturbance, defined as at least one sleep problem occurring on 15 or more nights in the past month. Most participants (86%) reported that sleep problems were due to their current pain. Approximately 80% of participants reported using cannabis in the past 6 months to improve sleep and, among these participants, cannabis was rated as helpful for improving sleep. Sleep-related cannabis side effects were rare (35%), but sleep-related cannabis withdrawal symptoms were relatively common (65%). Statistically significant correlates of past 1-month sleep disturbance included a) being female, b) being white, c) being on disability, d) not having a medical cannabis card, and e) frequency of using cannabis to help sleep.

CONCLUSIONS

Sleep problems are highly prevalent and frequent in medical cannabis patients and are closely tied to pain. Sleep-related cannabis withdrawal symptoms are relatively common but their clinical relevance is unknown. The association between frequency of cannabis use to help sleep with higher odds of sleep problems will need to be clarified by longitudinal studies.

摘要

目的

在医疗大麻患者样本中调查睡眠问题的发生率和相关因素。

程序

在密歇根州南部的医疗大麻诊所,年龄在 21 岁及以上(N=801,M 年龄=45.8)、因慢性疼痛寻求医疗大麻认证(首次或续证)的成年人完成了大麻使用、睡眠、疼痛和其他相关构念的基线测量。

发现

样本中有一半以上(59%)符合过去 1 个月睡眠障碍的标准,定义为过去一个月中至少有 15 个晚上出现睡眠问题。大多数参与者(86%)表示睡眠问题是由于他们目前的疼痛引起的。大约 80%的参与者报告在过去 6 个月内使用大麻来改善睡眠,在这些参与者中,大麻被认为有助于改善睡眠。与睡眠相关的大麻副作用很少见(35%),但与睡眠相关的大麻戒断症状相对常见(65%)。过去 1 个月睡眠障碍的显著相关因素包括:a)女性,b)白人,c)残疾,d)没有医疗大麻卡,e)使用大麻帮助睡眠的频率。

结论

睡眠问题在医疗大麻患者中非常普遍且频繁,与疼痛密切相关。与睡眠相关的大麻戒断症状较为常见,但它们的临床意义尚不清楚。需要通过纵向研究来阐明使用大麻帮助睡眠的频率与更高的睡眠问题发生率之间的关联。

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