Myc-1在小鼠15号染色体上位于Ly-6--Sis--Gdc-1连锁群的着丝粒侧。
Myc-1 is centromeric to the linkage group Ly-6--Sis--Gdc-1 on mouse chromosome 15.
作者信息
Huppi K, Duncan R, Potter M
机构信息
Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892.
出版信息
Immunogenetics. 1988;27(3):215-9. doi: 10.1007/BF00346589.
A survey of wild mouse DNA with a c-myc exon 1 probe revealed a Taq I restriction fragment length polymorphism (RFLP) among Mus species. As a result of this Taq I RFLP, a cross between Mus musculus domesticus and BALB/cJ permitted the positioning of Myc-1 on chromosome 15 with respect to Ly-6, Sis, and Gdc-1. Compilation of the recombination frequency generated from this cross with published cytogenetic and plasma-cytoma somatic cell hybrid data suggests the following chromosome 15 orientation: centromere--Myc-1--Ly-6--Sis--Gdc-1--telomere. This gene order is consistent with conservation of man-mouse synteny.
用c-myc外显子1探针检测野生小鼠DNA，结果显示小家鼠（Mus species）之间存在Taq I限制性片段长度多态性（RFLP）。由于这种Taq I RFLP，小家鼠（Mus musculus domesticus）与BALB/cJ杂交后，得以将Myc-1基因定位在15号染色体上，相对于Ly-6、Sis和Gdc-1基因。结合此次杂交产生的重组频率数据以及已发表的细胞遗传学和浆细胞瘤体细胞杂交数据，推测出15号染色体有如下排列顺序：着丝粒--Myc-1--Ly-6--Sis--Gdc-1--端粒。这种基因排序与人-鼠同线性的保守性一致。
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