• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
New Advances and Challenges of Targeting Cancer Stem Cells.靶向癌症干细胞的新进展与挑战
Cancer Res. 2017 Oct 1;77(19):5222-5227. doi: 10.1158/0008-5472.CAN-17-0054. Epub 2017 Sep 19.
2
Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance.癌症干细胞:靶向癌症的根源、转移的种子以及治疗耐药性的来源。
Cancer Res. 2015 Mar 15;75(6):924-9. doi: 10.1158/0008-5472.CAN-14-3225. Epub 2015 Jan 20.
3
Emerging functional markers for cancer stem cell-based therapies: Understanding signaling networks for targeting metastasis.基于癌症干细胞的治疗方法的新兴功能标志物:了解用于靶向转移的信号网络。
Semin Cancer Biol. 2018 Dec;53:90-109. doi: 10.1016/j.semcancer.2018.06.006. Epub 2018 Jun 30.
4
Insights into new mechanisms and models of cancer stem cell multidrug resistance.癌症干细胞多药耐药性新机制和新模型的研究进展。
Semin Cancer Biol. 2020 Feb;60:166-180. doi: 10.1016/j.semcancer.2019.07.022. Epub 2019 Jul 29.
5
Cancer Stem Cells and Targeting Strategies.癌症干细胞与靶向策略。
Cells. 2019 Aug 18;8(8):926. doi: 10.3390/cells8080926.
6
Targeting cancer stem cells to suppress acquired chemotherapy resistance.针对癌症干细胞以抑制获得性化疗耐药性。
Oncogene. 2014 Sep 4;33(36):4451-63. doi: 10.1038/onc.2013.411. Epub 2013 Oct 7.
7
Cancer Stem Cells: Basic Concepts and Therapeutic Implications.癌症干细胞:基本概念与治疗意义。
Annu Rev Pathol. 2016 May 23;11:47-76. doi: 10.1146/annurev-pathol-012615-044438.
8
Targeting Cancer Stemness in the Clinic: From Hype to Hope.靶向肿瘤干细胞:从炒作到希望。
Cell Stem Cell. 2019 Jan 3;24(1):25-40. doi: 10.1016/j.stem.2018.11.017. Epub 2018 Dec 27.
9
Cancer stem cell (CSC) resistance drivers.癌症干细胞(CSC)耐药性驱动因素。
Life Sci. 2019 Oct 1;234:116781. doi: 10.1016/j.lfs.2019.116781. Epub 2019 Aug 17.
10
Cancer stem cells and chemoresistance: The smartest survives the raid.癌症干细胞与化疗耐药性:最聪明的细胞在侵袭中存活下来。
Pharmacol Ther. 2016 Apr;160:145-58. doi: 10.1016/j.pharmthera.2016.02.008. Epub 2016 Feb 17.

引用本文的文献

1
Computational ranking identifies Plexin-B2 in circulating tumor cell clustering with monocytes in breast cancer metastasis.计算排序在乳腺癌转移中循环肿瘤细胞与单核细胞的聚集过程中鉴定出丛状蛋白-B2。
Nat Commun. 2025 Aug 16;16(1):7649. doi: 10.1038/s41467-025-62862-z.
2
Simultaneous Targeting of NQO1 and SOD1 Eradicates Breast Cancer Stem Cells via Mitochondrial Futile Redox Cycling.同时靶向NQO1和SOD1通过线粒体无效氧化还原循环消除乳腺癌干细胞。
Cancer Res. 2024 Dec 16;84(24):4264-4282. doi: 10.1158/0008-5472.CAN-24-0800.
3
Aberrant activation of the CD45-Wnt signaling axis promotes stemness and therapy resistance in colorectal cancer cells.CD45-Wnt 信号轴的异常激活促进结直肠癌细胞的干性和治疗耐药性。
Theranostics. 2021 Aug 11;11(18):8755-8770. doi: 10.7150/thno.63446. eCollection 2021.
4
Better together: circulating tumor cell clustering in metastatic cancer.联合起来更强大:转移性癌症中的循环肿瘤细胞聚集。
Trends Cancer. 2021 Nov;7(11):1020-1032. doi: 10.1016/j.trecan.2021.07.001. Epub 2021 Sep 1.
5
ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer.ICAM1 启动乳腺癌肺转移中的 CTC 簇形成和跨内皮迁移。
Nat Commun. 2021 Aug 11;12(1):4867. doi: 10.1038/s41467-021-25189-z.
6
EGFR inhibition blocks cancer stem cell clustering and lung metastasis of triple negative breast cancer.表皮生长因子受体抑制阻断三阴性乳腺癌肿瘤干细胞聚集和肺转移。
Theranostics. 2021 Apr 30;11(13):6632-6643. doi: 10.7150/thno.57706. eCollection 2021.
7
Zi Shen Decoction Inhibits Growth and Metastasis of Lung Cancer via Regulating the AKT/GSK-3/-Catenin Pathway.滋肾汤通过调控AKT/GSK-3/β-连环蛋白信号通路抑制肺癌的生长和转移。
Oxid Med Cell Longev. 2021 Mar 9;2021:6685282. doi: 10.1155/2021/6685282. eCollection 2021.
8
EpCAM-Mediated Cellular Plasticity Promotes Radiation Resistance and Metastasis in Breast Cancer.上皮细胞粘附分子介导的细胞可塑性促进乳腺癌的辐射抗性和转移。
Front Cell Dev Biol. 2021 Jan 6;8:597673. doi: 10.3389/fcell.2020.597673. eCollection 2020.
9
PHF20 Promotes Glioblastoma Cell Malignancies Through a /-Dependent Pathway.PHF20通过一种依赖β-连环蛋白的途径促进胶质母细胞瘤细胞的恶性增殖。
Front Oncol. 2020 Oct 6;10:573318. doi: 10.3389/fonc.2020.573318. eCollection 2020.
10
SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells.SPT6 驱动的无错误 DNA 修复可保护胶质母细胞瘤癌干细胞样细胞的基因组稳定性。
Nat Commun. 2020 Sep 18;11(1):4709. doi: 10.1038/s41467-020-18549-8.

本文引用的文献

1
Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity.细胞状态可塑性、干细胞、上皮-间质转化与肿瘤内异质性的产生
NPJ Breast Cancer. 2017 Apr 19;3:14. doi: 10.1038/s41523-017-0012-z. eCollection 2017.
2
A distinct role for Lgr5 stem cells in primary and metastatic colon cancer.Lgr5 干细胞在原发性和转移性结肠癌中的独特作用。
Nature. 2017 Mar 29;543(7647):676-680. doi: 10.1038/nature21713.
3
CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response.CD95/Fas通过诱导依赖STAT1的I型干扰素反应增加癌细胞的干性。
Cell Rep. 2017 Mar 7;18(10):2373-2386. doi: 10.1016/j.celrep.2017.02.037.
4
Analysis of Chemopredictive Assay for Targeting Cancer Stem Cells in Glioblastoma Patients.胶质母细胞瘤患者中靶向癌症干细胞的化学预测分析
Transl Oncol. 2017 Apr;10(2):241-254. doi: 10.1016/j.tranon.2017.01.008. Epub 2017 Feb 12.
5
A 17-gene stemness score for rapid determination of risk in acute leukaemia.一种用于快速确定急性白血病风险的 17 基因干性评分。
Nature. 2016 Dec 15;540(7633):433-437. doi: 10.1038/nature20598. Epub 2016 Dec 7.
6
Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance.KEAP1/NRF2和TP53突变在肺鳞状细胞癌发生发展及放射抗性中的作用
Cancer Discov. 2017 Jan;7(1):86-101. doi: 10.1158/2159-8290.CD-16-0127. Epub 2016 Sep 23.
7
miR-206 Inhibits Stemness and Metastasis of Breast Cancer by Targeting MKL1/IL11 Pathway.miR-206通过靶向MKL1/IL11通路抑制乳腺癌的干性和转移。
Clin Cancer Res. 2017 Feb 15;23(4):1091-1103. doi: 10.1158/1078-0432.CCR-16-0943. Epub 2016 Jul 19.
8
EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells.EphrinB2驱动胶质母细胞瘤干细胞样细胞的血管周围侵袭和增殖。
Elife. 2016 Jun 28;5:e14845. doi: 10.7554/eLife.14845.
9
Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.基于图像的胰腺腺癌治疗抗性检测与靶向治疗
Nature. 2016 Jun 16;534(7607):407-411. doi: 10.1038/nature17988. Epub 2016 Jun 6.
10
Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion.癌症干细胞分泌的巨噬细胞迁移抑制因子刺激髓源性抑制细胞功能并促进胶质母细胞瘤的免疫逃逸。
Stem Cells. 2016 Aug;34(8):2026-39. doi: 10.1002/stem.2393. Epub 2016 May 27.

靶向癌症干细胞的新进展与挑战

New Advances and Challenges of Targeting Cancer Stem Cells.

作者信息

Dashzeveg Nurmaa K, Taftaf Rokana, Ramos Erika K, Torre-Healy Luke, Chumakova Anastasia, Silver Daniel J, Alban Tyler J, Sinyuk Maksim, Thiagarajan Praveena S, Jarrar Awad M, Turaga Soumya M, Saygin Caner, Mulkearns-Hubert Erin, Hitomi Masahiro, Rich Jeremy N, Gerson Stanton L, Lathia Justin D, Liu Huiping

机构信息

Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio.

出版信息

Cancer Res. 2017 Oct 1;77(19):5222-5227. doi: 10.1158/0008-5472.CAN-17-0054. Epub 2017 Sep 19.

DOI:10.1158/0008-5472.CAN-17-0054
PMID:28928129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5833988/
Abstract

The second International Cancer Stem Cell Conference in Cleveland, Ohio, on September 20-23, 2016, convened 330 attendees from academic, industrial, and clinical organizations. It featured a debate on the concepts and challenges of the cancer stem cells (CSC) as well as CSC-centered scientific sessions on clinical trials, genetics and epigenetics, tumor microenvironment, immune suppression, metastasis, therapeutic resistance, and emerging novel concepts. The conference hosted 35 renowned speakers, 100 posters, 20 short talks, and a preconference workshop. The reported advances of CSC research and therapies fostered new collaborations across national and international borders, and inspired the next generation's young scientists. .

摘要

2016年9月20日至23日,第二届国际癌症干细胞大会在俄亥俄州克利夫兰召开,来自学术、产业和临床机构的330名与会者齐聚一堂。会议围绕癌症干细胞(CSC)的概念与挑战展开了一场辩论,并举办了以CSC为中心的科学会议,内容涵盖临床试验、遗传学与表观遗传学、肿瘤微环境、免疫抑制、转移、治疗抗性以及新兴的新概念。此次会议邀请了35位知名演讲者,展示了100份海报、20个简短演讲,并举办了会前研讨会。会上所报道的CSC研究和治疗进展促成了跨国界的新合作,也激励了下一代年轻科学家。