Dosoky Noura S, Satyal Prabodh, Gautam Tilak P, Setzer William N
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.
Department of Botany, Tribhuvan University, MMAMC, Biratnagar 56600, Nepal.
Medicines (Basel). 2016 Feb 26;3(1):7. doi: 10.3390/medicines3010007.
(L.) Jack, a small tropical evergreen shrub growing in Nepal, has numerous uses in traditional medicine for treatment of abdominal pain, diarrhea, stomach ache, headache, edema, thrombosis, and blood stasis. The present study investigated the chemical composition and bioactivities of the leaf essential oil from from Nepal. The essential oil from leaves was obtained by hydrodistillation and a detailed chemical analysis was conducted by gas chromatography-mass spectrometry (GC-MS). The essential oil was screened for antimicrobial activity using the microbroth dilution test, for nematicidal activity against , and for lethality against brine shrimp (). A total of 76 volatile components were identified from the essential oil. The major components were methyl palmitate (11.1%), isospathulenol (9.4%), (,)-geranyl linalool (5.3%), benzyl benzoate (4.2%), selin-6-en-4-ol (4.0%), β-caryophyllene (4.0%), germacrene B (3.6%), germacrene D (3.4%), and γ-elemene (3.2%). The essential oil showed no antibacterial activity, marginal antifungal activity against (MIC = 313 μg/mL), a moderate activity against (LC = 41 μg/mL), and a good nematicidal activity against (LC = 37 μg/mL).
(L.) 杰克是一种生长在尼泊尔的小型热带常绿灌木，在传统医学中有多种用途，可用于治疗腹痛、腹泻、胃痛、头痛、水肿、血栓形成和血瘀。本研究调查了来自尼泊尔的叶片精油的化学成分和生物活性。通过水蒸馏法获得叶片精油，并采用气相色谱 - 质谱联用仪（GC - MS）进行详细的化学分析。使用微量肉汤稀释试验筛选精油的抗菌活性，检测其对[某种线虫名称未给出]的杀线虫活性以及对卤虫（[卤虫名称未给出]）的致死性。从精油中总共鉴定出76种挥发性成分。主要成分有棕榈酸甲酯（11.1%）、异spathulenol（9.4%）、（±）- 香叶基芳樟醇（5.3%）、苯甲酸苄酯（4.2%）、芹子 - 6 - 烯 - 4 - 醇（4.0%）、β - 石竹烯（4.0%）、吉马烯B（3.6%）、吉马烯D（3.4%）和γ - 榄香烯（3.2%）。该精油未显示出抗菌活性，对[某种真菌名称未给出]有微弱的抗真菌活性（MIC = 313 μg/mL），对[某种线虫名称未给出]有中等活性（LC = 41 μg/mL），对[某种线虫名称未给出]有良好的杀线虫活性（LC = 37 μg/mL）。
