Hartman Richard E, Ross David M
Department of Psychology, Loma Linda University, 11130 Anderson Street. Loma Linda, California 92350, behavioralneuroscience@ gmail.com.
Department of Psychology, Loma Linda University, 11130 Anderson Street. Loma Linda, California 92350.
Front Biosci (Elite Ed). 2018 Jan 1;10(2):300-333. doi: 10.2741/e824.
Alzheimer's disease affects millions of people, yet, there are only a limited number approaches for it pharmacological treatment. Thus, identifying factors that decrease the risk of developing Alzheimer's disease is of paramount importance. A growing body of epidemiological and experimental evidence suggests that dietary fruits and vegetables have neuroprotective effects against the harmful effects of oxidative stress, neuroinflammation, and aging. These effects are mediated by various phytochemical compounds found in plants that exhibit antioxidant, anti-inflammatory, and other beneficial properties. This review addresses epidemiological and experimental evidence for the effects and potential mechanisms of several commonly consumed phytochemicals on neuropathology and outcomes of Alzheimer's disease. Based on available evidence, we suggest that regular consumption of bioactive phytochemicals from a variety of fruits and vegetables attenuates age- and insult-related neuropathology in Alzheimer's disease.
阿尔茨海默病影响着数百万人，然而，其药物治疗方法却非常有限。因此，确定降低患阿尔茨海默病风险的因素至关重要。越来越多的流行病学和实验证据表明，食用水果和蔬菜对氧化应激、神经炎症和衰老的有害影响具有神经保护作用。这些作用是由植物中发现的各种植物化学化合物介导的，这些化合物具有抗氧化、抗炎和其他有益特性。本综述阐述了几种常见食用植物化学物质对阿尔茨海默病神经病理学和预后影响及潜在机制的流行病学和实验证据。基于现有证据，我们建议经常食用各种水果和蔬菜中的生物活性植物化学物质可减轻阿尔茨海默病中与年龄和损伤相关的神经病理学。
