Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, Alabama 36849, USA.
Oxid Med Cell Longev. 2019 Jan 17;2019:8165707. doi: 10.1155/2019/8165707. eCollection 2019.
Type 2 diabetes mellitus is a complicated metabolic disorder characterized by hyperglycemia and glucose intolerance. Alzheimer's disease is a progressive brain disorder characterized by a chronic loss of cognitive and behavioral function. Considering the shared characteristics of both diseases, common therapeutic and preventive agents may be effective. Bioactive compounds such as polyphenols, vitamins, and carotenoids found in vegetables and fruits can have antioxidant and anti-inflammatory effects. These effects make them suitable candidates for the prevention or treatment of diabetes and Alzheimer's disease. Increasing evidence from cell or animal models suggest that bioactive compounds may have direct effects on decreasing hyperglycemia, enhancing insulin secretion, and preventing formation of amyloid plaques. The possible underlying molecular mechanisms are described in this review. More studies are needed to establish the clinical effects of bioactive compounds.
2 型糖尿病是一种以高血糖和葡萄糖耐量受损为特征的复杂代谢紊乱。阿尔茨海默病是一种进行性脑紊乱，其特征是慢性认知和行为功能丧失。考虑到这两种疾病的共同特征，共同的治疗和预防药物可能是有效的。蔬菜和水果中的生物活性化合物，如多酚、维生素和类胡萝卜素，具有抗氧化和抗炎作用。这些作用使它们成为预防或治疗糖尿病和阿尔茨海默病的合适候选物。越来越多的来自细胞或动物模型的证据表明，生物活性化合物可能对降低高血糖、增强胰岛素分泌和预防淀粉样斑块形成有直接作用。本综述描述了可能的潜在分子机制。还需要更多的研究来确定生物活性化合物的临床效果。
