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桑叶通过减轻 NEFA 信号和调节肠道微生物群缓解链脲佐菌素诱导的糖尿病大鼠。

Mulberry leaf alleviates streptozotocin-induced diabetic rats by attenuating NEFA signaling and modulating intestinal microflora.

机构信息

Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.

Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety), Ministry of Agriculture, Beijing, 100083, China.

出版信息

Sci Rep. 2017 Sep 21;7(1):12041. doi: 10.1038/s41598-017-12245-2.

DOI:10.1038/s41598-017-12245-2
PMID:28935866
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5608946/
Abstract

Improvement of hyperglycemia through dietotherapy/herbal remedy is an effective approach to treating diabetes. In this study, mulberry leaf, famous for silkworm's special food and therapeutic value without any side effects, alleviated diabetes by attenuating NEFA signaling and modulating intestinal microflora. Mulberry leaf treatment significantly reduce fasting blood-glucose and HbA1c, ameliorate the blood lipid profile and improve insulin resistance in streptozotocin-induced diabetic rats. Mechanistically, we found that mulberry leaf inhibited NEFA signaling by reducing downstream signaling in the NEFA pathway, further verified by reduced PKC and improved cellular energy homeostasis based on restored expression of PGC-1α, AK2, OXPHOS and adiponectin. Mulberry leaf treatment also restored the phyla Bacteroidetes and Proteobacteria and class Clostridia, which were associated with insulin resistance and diabetes. Our findings reveal that mulberry leaf is an edible with therapeutic potential for diabetes and may provide a novel dietotherapy/herbal remedy to the treatment of diabetes.

摘要

通过饮食疗法/草药疗法改善高血糖是治疗糖尿病的一种有效方法。在这项研究中，桑叶作为蚕的特殊食物和具有治疗价值且无任何副作用的草药而闻名，通过减弱 NEFA 信号和调节肠道微生物群来缓解糖尿病。桑叶治疗可显著降低空腹血糖和 HbA1c，改善链脲佐菌素诱导的糖尿病大鼠的血脂谱并改善胰岛素抵抗。在机制上，我们发现桑叶通过减少 NEFA 途径下游信号来抑制 NEFA 信号，这进一步通过减少 PKC 和改善基于 PGC-1α、AK2、OXPHOS 和脂联素表达恢复的细胞能量稳态得到验证。桑叶治疗还恢复了与胰岛素抵抗和糖尿病相关的门杆菌和变形菌以及纲梭菌。我们的研究结果表明，桑叶是一种具有治疗糖尿病潜力的可食用植物，可能为糖尿病的治疗提供一种新的饮食疗法/草药疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/635f/5608946/91f3e6a1f423/41598_2017_12245_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/635f/5608946/e3d4f6302b0e/41598_2017_12245_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/635f/5608946/df37afb47c06/41598_2017_12245_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/635f/5608946/cdbfd598d215/41598_2017_12245_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/635f/5608946/01932501ff8c/41598_2017_12245_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/635f/5608946/5b5bc93feb0c/41598_2017_12245_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/635f/5608946/91f3e6a1f423/41598_2017_12245_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/635f/5608946/e3d4f6302b0e/41598_2017_12245_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/635f/5608946/df37afb47c06/41598_2017_12245_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/635f/5608946/cdbfd598d215/41598_2017_12245_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/635f/5608946/01932501ff8c/41598_2017_12245_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/635f/5608946/5b5bc93feb0c/41598_2017_12245_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/635f/5608946/91f3e6a1f423/41598_2017_12245_Fig6_HTML.jpg

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