Dept of Neuroscience, Karolinska Institutet, Stockholm, Sweden; Dept of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Dept of Psychology, University of Zagreb, Zagreb, Croatia.
J Affect Disord. 2018 Jan 15;226:6-11. doi: 10.1016/j.jad.2017.09.017. Epub 2017 Sep 18.
Genetic research on depression and burnout has focused mostly on adverse factors, although various aspects in daily life related to positive coping and well-being have been shown to potentially be protective. Using a large genetically informative sample, we aim to explore the potential relationship between flow proneness and work-related depressive symptoms and burnout.
About 10,000 Swedish twins filled in the Swedish Flow Proneness Questionnaire, a subscale of the Hopkins Symptom Checklist (SCL) depression scale, and the Emotional Exhaustion subscale of the Maslach Burnout Inventory-General Survey. A higher score indicated more flow, less emotional exhaustion and less depression. The classical twin design and co-twin control analyses were applied.
Phenotypic correlations were .43 between depressive symptoms and flow proneness, .34 between burnout and flow proneness, and .62 between depressive symptoms and burnout. Broad-sense heritabilities (G) ranged between 33-35% for the three variables. Associations between the variables were due to significant genetic as well as non-shared environmental influences. Co-twin control analyses showed that associations remained significant when controlling for all genetic and shared familial factors, in line with a causal relationship.
Although the co-twin control design can test for consistency of associations with a causal relationship, it cannot unequivocally establish causality.
Genetic liability has a substantial influence on associations between flow proneness and emotional problems at work (depression, burnout). However, the presence of significant environmental correlations is in line with a (partly) causal relationship between flow and work related depression and burnout, which in turn may suggest that interventions which increase flow could potentially reduce emotional problems at work.
抑郁症和倦怠的遗传研究主要集中在不利因素上,尽管生活中与积极应对和幸福感相关的各个方面都被证明具有潜在的保护作用。本研究使用一个大型的遗传信息丰富的样本,旨在探索流畅倾向与工作相关的抑郁症状和倦怠之间的潜在关系。
约 10000 名瑞典双胞胎填写了瑞典流畅倾向问卷、霍普金斯症状清单(SCL)抑郁量表的一个子量表和 Maslach 倦怠量表-一般调查的情绪衰竭子量表。得分越高表示流畅度越高,情绪衰竭和抑郁程度越低。采用经典的双胞胎设计和同卵双胞胎对照分析。
抑郁症状与流畅倾向之间的表型相关系数为.43,倦怠与流畅倾向之间的表型相关系数为.34,抑郁症状与倦怠之间的表型相关系数为.62。三个变量的广义遗传力(G)范围在 33-35%之间。这些变量之间的关联是由于遗传和非共享环境因素的显著影响。同卵双胞胎对照分析表明,当控制所有遗传和共享家庭因素时,关联仍然显著,这与因果关系一致。
虽然同卵双胞胎对照设计可以测试与因果关系一致的关联,但不能明确确定因果关系。
流畅倾向与工作中情绪问题(抑郁、倦怠)之间的关联具有显著的遗传易感性。然而,环境相关性的存在符合流畅性与工作相关的抑郁和倦怠之间的(部分)因果关系,这反过来又表明,增加流畅性的干预措施可能会潜在地降低工作中的情绪问题。