Danyuttapolchai Junya, Kittimunkong Somyot, Nateniyom Sriprapa, Painujit Sutthapa, Klinbuayaem Virat, Maipanich Nuanpun, Maokamnerd Yongyut, Pevzner Eric, Whitehead Sara, Kanphukiew Apiratee, Monkongdee Patama, Martin Michael
Thailand Ministry of Public Health-U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi province, Thailand.
Bureau of Vector-Borne Diseases, Department of Disease Control, Thailand Ministry of Public Health, Nonthaburi province, Thailand.
PLoS One. 2017 Sep 26;12(9):e0184986. doi: 10.1371/journal.pone.0184986. eCollection 2017.
Treatment of people living with HIV (PLHIV) with latent tuberculosis (TB) infection using isoniazid preventive therapy (IPT) can reduce the risk of TB disease, however, the scale-up of IPT among PLHIV in Thailand and worldwide has been slow. To hasten the implementation of IPT in Thailand, we developed IPT implementation training curricula and tools for health care providers and implemented IPT services in seven large government hospitals. Of the 659 PLHIV enrolled, 272 (41.3%) reported symptoms of TB and 39 (14.3% of those with TB symptoms) were diagnosed with TB. A total of 346 (52.4%) participants were eligible for IPT; 318 (91.9%) of these participants opted to have a tuberculin skin test (TST) and 52 (16.3% of those who had a TST) had a positive TST result. Among the 52 participants with a positive TST, 46 (88.5%) initiated and 39 (75.0%) completed 9 months of IPT: physicians instructed three participants to stop IPT, two participants were lost to follow-up, one chose to stop therapy, and one developed TB. IPT can be implemented among PLHIV in Thailand and could reduce the burden of TB in the country.
对合并潜伏性结核感染的艾滋病病毒感染者（PLHIV）采用异烟肼预防性治疗（IPT）可降低结核病发病风险，然而，泰国及全球范围内PLHIV中IPT的推广速度一直较慢。为加快泰国IPT的实施，我们为医疗服务提供者开发了IPT实施培训课程和工具，并在七家大型政府医院提供IPT服务。在纳入的659名PLHIV中，272名（41.3%）报告有结核病症状，其中39名（有结核病症状者的14.3%）被诊断为结核病。共有346名（52.4%）参与者符合IPT条件；这些参与者中有318名（91.9%）选择进行结核菌素皮肤试验（TST），其中52名（进行TST者的16.3%）TST结果呈阳性。在52名TST结果呈阳性的参与者中，46名（88.5%）开始接受并39名（75.0%）完成了9个月的IPT：医生指示三名参与者停止IPT，两名参与者失访，一名选择停止治疗，一名患上结核病。IPT可在泰国的PLHIV中实施，并可减轻该国的结核病负担。
