Libertellenones O-S 和 Eutypellenones A 和 B，来自北极真菌 Eutypella sp. D-1 的 Pimarane 二萜衍生物。
Libertellenones O-S and Eutypellenones A and B, Pimarane Diterpene Derivatives from the Arctic Fungus Eutypella sp. D-1.
机构信息
Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences , Second Military Medical University , Shanghai 200433 , People's Republic of China.
Marine Biopharmaceutical Institute , Second Military Medical University , Shanghai 200433 , People's Republic of China.
出版信息
J Nat Prod. 2018 Jul 27;81(7):1553-1560. doi: 10.1021/acs.jnatprod.8b00039. Epub 2018 Jun 27.
Seven new pimarane-type diterpene derivatives, libertellenones O-S (1-5) and eutypellenones A and B (6 and 7), together with two known compounds (8 and 9), were isolated from the culture of Eutypella sp. D-1 obtained from high-latitude soil of the Arctic. Their structures were elucidated from spectroscopic data, as well as experimental and calculated electronic circular dichroism (ECD) analysis. Structurally, compounds 1-5 possess a cyclopropyl-fused pimarane diterpene moiety, whereas compounds 6 and 7 share an unusual cyclobutyl-fused pimarane diterpene skeleton. Compounds 1-9 exhibited cytotoxicities against HeLa, MCF-7, HCT-116, PANC-1, and SW1990 cells, with IC values in the range of 0.3 to 29.4 μM. Compounds 6 and 7 could dose-dependently inhibit the activity of NF-κB and exhibited significantly inhibitory effects on nitric oxide production induced by lipopolysaccharide.
从北极高纬度土壤中分离到的 Eutypella sp. D-1 的培养物中，分离得到了 7 种新的匹马烷型二萜衍生物，即 libertellenones O-S（1-5）和 eutypellenones A 和 B（6 和 7），以及两种已知化合物（8 和 9）。它们的结构通过光谱数据以及实验和计算电子圆二色性（ECD）分析来阐明。结构上，化合物 1-5 具有环丙基稠合的匹马烷二萜部分，而化合物 6 和 7 则具有不寻常的环丁基稠合的匹马烷二萜骨架。化合物 1-9 对 HeLa、MCF-7、HCT-116、PANC-1 和 SW1990 细胞具有细胞毒性，IC 值范围为 0.3 至 29.4 μM。化合物 6 和 7 可剂量依赖性抑制 NF-κB 的活性，并对脂多糖诱导的一氧化氮产生具有显著的抑制作用。
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