Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Malaysia.
Biomedical Science Programme, School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.
Nutrients. 2017 Sep 26;9(10):1060. doi: 10.3390/nu9101060.
Osteoarthritis is a major cause of morbidity among the elderly worldwide. It is a disease characterized by localized inflammation of the joint and destruction of cartilage, leading to loss of function. Impaired chondrocyte repair mechanisms, due to inflammation, oxidative stress and autophagy, play important roles in the pathogenesis of osteoarthritis. Olive and its derivatives, which possess anti-inflammatory, antioxidant and autophagy-enhancing activities, are suitable candidates for therapeutic interventions for osteoarthritis. This review aimed to summarize the current evidence on the effects of olive and its derivatives, on osteoarthritis and chondrocytes. The literature on animal and human studies has demonstrated a beneficial effect of olive and its derivatives on the progression of osteoarthritis. In vitro studies have suggested that the augmentation of autophagy (though sirtuin-1) and suppression of inflammation by olive polyphenols could contribute to the chondroprotective effects of olive polyphenols. More research and well-planned clinical trials are required to justify the use of olive-based treatment in osteoarthritis.
骨关节炎是全球老年人发病率较高的主要原因。这种疾病的特征是关节局部炎症和软骨破坏，导致功能丧失。受损的软骨细胞修复机制，由于炎症、氧化应激和自噬，在骨关节炎的发病机制中发挥重要作用。橄榄及其衍生物具有抗炎、抗氧化和增强自噬的作用，是治疗骨关节炎的合适候选药物。本综述旨在总结橄榄及其衍生物对骨关节炎和软骨细胞的影响的现有证据。动物和人体研究文献表明，橄榄及其衍生物对骨关节炎的进展有有益的作用。体外研究表明，橄榄多酚通过 SIRT1 增强自噬和抑制炎症可能有助于橄榄多酚的软骨保护作用。需要更多的研究和精心设计的临床试验来证明基于橄榄的治疗方法在骨关节炎中的应用。
