Duggan D B, Ehrlich G D, Davey F P, Kwok S, Sninsky J, Goldberg J, Baltrucki L, Poiesz B J
Division of Hematology/Oncology, SUNY Health Science Center, Syracuse 13210.
Blood. 1988 Apr;71(4):1027-32.
A patient with a localized HTLV-I-associated lymphoproliferative disease that was misdiagnosed as Hodgkin's disease is presented. The patient's serum was negative for HTLV-I antibodies by enzyme-linked immunosorbent assay (ELISA), Western blot, and radioimmunoprecipitation. Tumor tissue DNA was negative for HTLV-I by Southern blotting but was positive for distinct HTLV-I sequences when subjected to DNA amplification using the polymerase chain reaction. We conclude that the clinical and pathologic diagnosis of HTLV-I-related lymphoma can be difficult and can be confused with Hodgkin's disease. Extremely sensitive molecular biological techniques may be required to establish a diagnosis of HTLV-I-induced lymphoma.
本文报告了一例局限性人嗜T淋巴细胞病毒I型（HTLV-I）相关淋巴增殖性疾病患者，该患者曾被误诊为霍奇金病。通过酶联免疫吸附测定（ELISA）、蛋白质印迹法和放射免疫沉淀法检测，患者血清HTLV-I抗体均为阴性。经Southern印迹法检测，肿瘤组织DNA中HTLV-I为阴性，但采用聚合酶链反应进行DNA扩增时，可检测到明显的HTLV-I序列，结果呈阳性。我们得出结论，HTLV-I相关淋巴瘤的临床和病理诊断可能存在困难，且可能与霍奇金病相混淆。可能需要极其敏感的分子生物学技术来确诊HTLV-I诱导的淋巴瘤。
