Antonets K S, Nizhnikov A A
a All-Russia Research Institute for Agricultural Microbiology , St. Petersburg , Russian Federation.
b Department of Genetics and Biotechnology , St. Petersburg State University , St. Petersburg, Russian Federation.
Prion. 2017 Sep 3;11(5):300-312. doi: 10.1080/19336896.2017.1377875.
Amyloids represent protein fibrils that have highly ordered structure with unique physical and chemical properties. Amyloids have long been considered lethal pathogens that cause dozens of incurable diseases in humans and animals. Recent data show that amyloids may not only possess pathogenic properties but are also implicated in the essential biological processes in a variety of prokaryotes and eukaryotes. Functional amyloids have been identified in archaea, bacteria, fungi, and animals, including humans. Plants are one of the most poorly studied groups of organisms in the field of amyloid biology. Although amyloid properties have not been shown under native conditions for any plant protein, studies demonstrating amyloid properties for a set of plant proteins in vitro or in heterologous systems in vivo have been published in recent years. In this review, we systematize the data on the amyloidogenic proteins of plants and their functions and discuss the perspectives of identifying novel amyloids using bioinformatic and proteomic approaches.
淀粉样蛋白是具有高度有序结构且具备独特物理和化学性质的蛋白质原纤维。长期以来，淀粉样蛋白一直被视为致命病原体，可在人类和动物中引发数十种无法治愈的疾病。最近的数据表明，淀粉样蛋白不仅可能具有致病特性，还参与了多种原核生物和真核生物的基本生物学过程。在古生菌、细菌、真菌以及包括人类在内的动物中都已鉴定出功能性淀粉样蛋白。植物是淀粉样蛋白生物学领域中研究最少的生物群体之一。尽管尚未在天然条件下证明任何植物蛋白具有淀粉样蛋白特性，但近年来已有研究表明一组植物蛋白在体外或体内异源系统中具有淀粉样蛋白特性。在这篇综述中，我们对植物淀粉样生成蛋白及其功能的数据进行了系统化整理，并讨论了使用生物信息学和蛋白质组学方法鉴定新型淀粉样蛋白的前景。
