Wang Wei, Hou Jin, Lv Deyong, Liang Wen, Jiang Xinqing, Han Hongbin, Quan Xianyue
Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China.
Department of Radiology, Guangzhou First People's Hospital, Guangzhou, Guangdong 510180, P.R. China.
Exp Ther Med. 2017 Sep;14(3):2078-2084. doi: 10.3892/etm.2017.4786. Epub 2017 Jul 12.
The present study investigated the application of the T and T relaxation mapping magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in the evaluation of intervertebral disc degeneration (IDD). A total of 93 asymptomatic subjects were imaged with T and T mapping, as well as DWI. Pfirrmann grading was performed and correlation analysis was conducted for T, T and DWI results with the grading results and age. Pfirrmann grading indicated 69 cases of grade I, 240 cases of grade II, 101 cases of grade III, 43 cases of grade IV and 12 cases of grade V. MRI showed that the T values of the nucleus pulposi at L4/5 and L5/S1 were significantly reduced (P<0.05) and no significant differences were observed in the T values compared with the values of the nucleus pulposus at L1/2, L2/3 and L3/4. The apparent diffusion coefficient (ADC) values of L1/2 were significantly decreased from L2/3 and L3/4 (P<0.05). Correlation analysis revealed that the T, T, and ADC values were positively correlated with each other. Moreover, the Tvalues were significantly decreased with the increase of Pfirrmann grades (P<0.05), with the exception of grades IV and V. However, T and ADC values were not significantly different between grades I and II or IV and V. In addition, the T, T and ADC values were significantly decreased with the increase of age in patients with IDD (P<0.05). T and T mapping and DWI are promising techniques for the diagnosis of IDD, which may be useful in determining the appropriate prevention and treatment options for the disease.
本研究探讨了T2和T2弛豫映射磁共振成像（MRI）及扩散加权成像（DWI）在椎间盘退变（IDD）评估中的应用。共对93名无症状受试者进行了T2和T2映射以及DWI成像。进行了Pfirrmann分级，并对T2、T2和DWI结果与分级结果及年龄进行了相关性分析。Pfirrmann分级显示，I级69例，II级240例，III级101例，IV级43例，V级12例。MRI显示，L4/5和L5/S1椎间盘髓核的T2值显著降低（P<0.05），与L1/2、L2/3和L3/4椎间盘髓核的T2值相比，未观察到显著差异。L1/2的表观扩散系数（ADC）值较L2/3和L3/4显著降低（P<0.05）。相关性分析显示，T2、T2和ADC值之间呈正相关。此外，除IV级和V级外，T2值随Pfirrmann分级增加而显著降低（P<0.05）。然而，I级和II级或IV级和V级之间的T2和ADC值无显著差异。此外，IDD患者中，T2、T2和ADC值随年龄增加而显著降低（P<0.05）。T2和T2*映射及DWI是诊断IDD的有前景的技术，可能有助于确定该疾病的适当预防和治疗方案。
