Bonaccio M, Ruggiero E, Di Castelnuovo A, Costanzo S, Persichillo M, De Curtis A, Cerletti C, Donati M B, de Gaetano G, Iacoviello L
Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, 86077 Pozzilli, IS, Italy.
Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, 86077 Pozzilli, IS, Italy.
Nutr Metab Cardiovasc Dis. 2017 Oct;27(10):865-873. doi: 10.1016/j.numecd.2017.08.004. Epub 2017 Aug 23.
Fish consumption reportedly reduces the risk of heart disease, but the evidence of cardiovascular advantages associated with fish intake within Mediterranean cohorts is limited. The aim of this study was to test the association between fish intake and risk of composite coronary heart disease (CHD) and stroke in a large population-based cohort adhering to Mediterranean Diet.
Prospective analysis on 20,969 subjects free from cardiovascular disease at baseline, enrolled in the Moli-sani study (2005-2010). Food intake was recorded by the Italian version of the EPIC food frequency questionnaire. Hazard ratios were calculated by using multivariable Cox-proportional hazard models. During a median follow-up of 4.3 years, a total of 352 events occurred (n of CHD = 287 and n of stroke = 66). After adjustment for a large panel of covariates, fish intake ≥4 times per week was associated with 40% reduced risk of composite CHD and stroke (HR = 0.60; 95%CI 0.40-0.90), and with 40% lower risk of CHD (HR = 0.60; 95%CI 0.38-0.94) as compared with subjects in the lowest category of intake (<2 times/week). A similar trend of protection was found for stroke risk although results were not significant (HR = 0.62; 95%CI 0.26-1.51). When fish types were considered, protection against the composite outcome and CHD was confined to fatty fish intake.
Fish intake was associated with reduced risk of composite fatal and non-fatal CHD and stroke in a general Mediterranean population. The favourable association was likely to be driven by fatty fish.
据报道，食用鱼类可降低患心脏病的风险，但在地中海人群中，鱼类摄入与心血管益处之间的证据有限。本研究的目的是在遵循地中海饮食的大规模人群队列中，检验鱼类摄入与复合性冠心病（CHD）和中风风险之间的关联。
对莫利萨尼研究（2005 - 2010年）中20969名基线时无心血管疾病的受试者进行前瞻性分析。食物摄入量通过意大利版的EPIC食物频率问卷进行记录。使用多变量Cox比例风险模型计算风险比。在中位随访4.3年期间，共发生352起事件（冠心病287例，中风66例）。在对大量协变量进行调整后，每周食用鱼类≥4次与复合性冠心病和中风风险降低40%相关（风险比=0.60；95%置信区间0.40 - 0.90），与摄入量最低类别（<2次/周）的受试者相比，患冠心病的风险降低40%（风险比=0.60；95%置信区间0.38 - 0.94）。虽然结果不显著（风险比=0.62；95%置信区间0.26 - 1.51），但在中风风险方面也发现了类似的保护趋势。当考虑鱼类种类时，对复合结局和冠心病的保护仅限于食用富含脂肪的鱼类。
在地中海普通人群中，鱼类摄入与复合性致命和非致命性冠心病及中风风险降低相关。这种有利关联可能是由富含脂肪的鱼类驱动的。
