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溃疡性结肠炎成人、儿童和青少年的管理——简明指南

Ulcerative colitis: management in adults, children and young people - concise guidance .

机构信息

Academic Unit of Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Tunbridge Wells Hospital, Kent, UK.

出版信息

Clin Med (Lond). 2017 Oct;17(5):429-433. doi: 10.7861/clinmedicine.17-5-429.

DOI:10.7861/clinmedicine.17-5-429
PMID:28974592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6301924/
Abstract

Ulcerative colitis is a chronic, relapsing and remitting -inflammatory disease of the colon and rectum. Effective -management requires prompt recognition and treatment of those with acute relapses as well as appropriate choice and monitoring of drugs for maintenance of remission. This therefore involves specialist gastroenterology teams as well as acute and general physicians and primary care clinicians. Treatment options need to be discussed with those with -ulcerative colitis and their families and appropriate information provided. This concise guideline focuses (with the generalist particularly in mind) on recommendations from the National Institute for Health and Care Excellence clinical guideline 166 considered of key importance for implementation.

摘要

溃疡性结肠炎是一种累及结肠和直肠的慢性、复发和缓解性炎症性疾病。有效的管理需要及时识别和治疗急性复发患者,并适当选择和监测维持缓解的药物。因此,这需要消化内科专家团队、急性和普通内科医生以及初级保健临床医生的共同参与。需要与溃疡性结肠炎患者及其家属讨论治疗选择,并提供适当的信息。本简要指南(特别是考虑到通科医生)重点关注了国家卫生与保健卓越研究所临床指南 166 中的建议,这些建议对于实施具有关键重要性。

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本文引用的文献

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Infliximab versus ciclosporin for steroid-resistant acute severe ulcerative colitis (CONSTRUCT): a mixed methods, open-label, pragmatic randomised trial.英夫利昔单抗与环孢素治疗激素抵抗性急性重度溃疡性结肠炎(CONSTRUCT):一项混合方法、开放标签、实用随机试验。
Lancet Gastroenterol Hepatol. 2016 Sep;1(1):15-24. doi: 10.1016/S2468-1253(16)30003-6.
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Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease.欧洲关于炎症性肠病机会性感染预防、诊断和管理的第二项循证共识
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Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial.环孢素与英夫利昔单抗治疗对静脉用类固醇无效的重度溃疡性结肠炎患者的疗效比较:一项平行、开放标签、随机对照试验。
Lancet. 2012 Dec 1;380(9857):1909-15. doi: 10.1016/S0140-6736(12)61084-8. Epub 2012 Oct 10.
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