Yun Zhi-Yuan, Li Na, Zhang Xin, Zhang Huan, Bu Yue, Sun Yuxiang, Liu Tiemin, Wang Rui-Tao, Yu Kai-Jiang
Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
Department of Intensive Care Unit, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
Oncotarget. 2017 Mar 4;8(37):62600-62605. doi: 10.18632/oncotarget.15898. eCollection 2017 Sep 22.
Activated platelets are involved in cancer development and progression. Mean platelet volume (MPV) and platelet distribution width (PDW) are early indexes of platelet activation. The objectives of this study were to investigate the ability of MPV, PDW and carcinoembryonic antigen (CEA) individually or in combination, to distinguish between gastric cancer and gastric ulcer. The study involved 194 patients with gastric cancer, 191 patients with gastric ulcer, and 185 control subjects. Subjects' characteristics and hematologic tests data at initial diagnosis were collected. We found that MPV levels are significantly increased and PDW levels are significantly reduced in patients with gastric ulcer and in control subjects compared with those in gastric cancer. When the area under the curve (AUC) was used to analyze control subjects gastric cancer, the combination of PDW and CEA exhibited a significantly larger AUC of 0.939 (0.910-0.961) compared with the combination of MPV and CEA ( = 0.0045). When AUC was used to analyze gastric ulcer gastric cancer, PDW alone had the high specificity (98.5%) and high sensitivity (97.4%). In conclusion, combined use of MPV, PDW and CEA can accurately distinguish gastric cancer from gastric ulcer and controls. Further studies in larger samples are warranted.
活化血小板参与癌症的发生和发展。平均血小板体积（MPV）和血小板分布宽度（PDW）是血小板活化的早期指标。本研究的目的是探讨MPV、PDW和癌胚抗原（CEA）单独或联合使用区分胃癌和胃溃疡的能力。该研究纳入了194例胃癌患者、191例胃溃疡患者和185例对照者。收集了受试者初诊时的特征和血液学检测数据。我们发现，与胃癌患者相比，胃溃疡患者和对照者的MPV水平显著升高，PDW水平显著降低。当用曲线下面积（AUC）分析对照者与胃癌患者时，与MPV和CEA联合使用相比，PDW和CEA联合使用的AUC显著更大，为0.939（0.910 - 0.961）（P = 0.0045）。当用AUC分析胃溃疡患者与胃癌患者时，单独的PDW具有高特异性（98.5%）和高敏感性（97.4%）。总之，联合使用MPV、PDW和CEA可以准确区分胃癌与胃溃疡及对照者。有必要进行更大样本量的进一步研究。
