Hiranmayi K Vidya, Sirisha K, Ramoji Rao M V, Sudhakar P
Post Graduate Student, Department of Periodontics and Implantology, Drs S and NR Siddhartha Institute of Dental Sciences, Krishna District, Andhra Pradesh, India.
Reader, Department of Periodontics and Implantology, Drs S and NR Siddhartha Institute of Dental Sciences, Krishna District, Andhra Pradesh, India.
J Pharm Bioallied Sci. 2017 Jul-Sep;9(3):155-163. doi: 10.4103/jpbs.JPBS_288_16.
Periodontitis is a polymicrobial disease caused by complex interactions between distinct pathogens in a biofilm resulting in the destruction of periodontal tissues. It seems evident that unknown microorganisms might be involved in onset or progression of periodontitis. For many decades, research in the field of oral microbiology failed to identify certain subgingival microbiota due to technical limitations but, over a period of 12 years using molecular approaches and sequencing techniques, it became feasible to reveal the existence of new periodontal pathogens. Therefore, it is evident that in addition to conventional periodontal pathogens, other microbes might be involved in onset and progression of periodontitis. The novel pathogens enlisted under periodontal phylogeny include , , , , , , , , and . The polymicrobial etiology of periodontitis has been elucidated by comprehensive techniques, and studies throwing light on the possible virulence mechanisms possessed by these novel periodontal pathogens are enlisted.
牙周炎是一种由生物膜中不同病原体之间复杂相互作用引起的多微生物疾病，会导致牙周组织破坏。显然，未知微生物可能参与牙周炎的发病或进展。几十年来，由于技术限制，口腔微生物学领域的研究未能识别某些龈下微生物群，但在12年的时间里，使用分子方法和测序技术，揭示新的牙周病原体的存在变得可行。因此，很明显，除了传统的牙周病原体外，其他微生物可能也参与牙周炎的发病和进展。牙周系统发生学中登记的新型病原体包括 、 、 、 、 、 、 、 和 。牙周炎的多微生物病因已通过综合技术阐明，并且列举了揭示这些新型牙周病原体可能具有的毒力机制的研究。
