Chen Yi-Ting, Kolhatkar Arati G, Zenasni Oussama, Xu Shoujun, Lee T Randall
Department of Chemistry and the Texas Center for Superconductivity, University of Houston, Houston, TX 77204, USA.
Sensors (Basel). 2017 Oct 10;17(10):2300. doi: 10.3390/s17102300.
Magnetic particles are widely used as signal labels in a variety of biological sensing applications, such as molecular detection and related strategies that rely on ligand-receptor binding. In this review, we explore the fundamental concepts involved in designing magnetic particles for biosensing applications and the techniques used to detect them. First, we briefly describe the magnetic properties that are important for bio-sensing applications and highlight the associated key parameters (such as the starting materials, size, functionalization methods, and bio-conjugation strategies). Subsequently, we focus on magnetic sensing applications that utilize several types of magnetic detection techniques: spintronic sensors, nuclear magnetic resonance (NMR) sensors, superconducting quantum interference devices (SQUIDs), sensors based on the atomic magnetometer (AM), and others. From the studies reported, we note that the size of the MPs is one of the most important factors in choosing a sensing technique.
磁性粒子在各种生物传感应用中被广泛用作信号标记，例如分子检测以及依赖配体-受体结合的相关策略。在本综述中，我们探讨了用于生物传感应用的磁性粒子设计所涉及的基本概念以及用于检测它们的技术。首先，我们简要描述对生物传感应用重要的磁性特性，并突出相关的关键参数（如起始材料、尺寸、功能化方法和生物共轭策略）。随后，我们重点关注利用几种类型磁性检测技术的磁传感应用：自旋电子传感器、核磁共振（NMR）传感器、超导量子干涉器件（SQUID）、基于原子磁力计（AM）的传感器等。从所报道的研究中，我们注意到磁性粒子的尺寸是选择传感技术时最重要的因素之一。
