通过纳米技术调节免疫系统。
Modulating the immune system through nanotechnology.
机构信息
Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Campus Vida, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain; Department of Pharmacology, Pharmacy and Pharmaceutical Technology, School of Pharmacy, Campus Vida, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.
Department of Pharmacology, Pharmacy and Pharmaceutical Technology, School of Pharmacy, Campus Vida, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.
出版信息
Semin Immunol. 2017 Dec;34:78-102. doi: 10.1016/j.smim.2017.09.007. Epub 2017 Oct 9.
Abstract
Nowadays, nanotechnology-based modulation of the immune system is presented as a cutting-edge strategy, which may lead to significant improvements in the treatment of severe diseases. In particular, efforts have been focused on the development of nanotechnology-based vaccines, which could be used for immunization or generation of tolerance. In this review, we highlight how different immune responses can be elicited by tuning nanosystems properties. In addition, we discuss specific formulation approaches designed for the development of anti-infectious and anti-autoimmune vaccines, as well as those intended to prevent the formation of antibodies against biologicals.
摘要
如今，基于纳米技术的免疫系统调节被提出作为一种前沿策略，可能会显著改善严重疾病的治疗效果。特别是，人们致力于开发基于纳米技术的疫苗，这些疫苗可用于免疫接种或产生耐受性。在这篇综述中，我们强调了通过调整纳米系统的特性如何引发不同的免疫反应。此外，我们还讨论了专门设计用于开发抗感染和抗自身免疫疫苗的特定配方方法，以及旨在防止针对生物制剂形成抗体的方法。
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