Alvarado-Esquivel Cosme, Sandoval-Carrillo Ada A, Vazquez-Alaniz Fernando, Salas-Pacheco José M, Hernández-Tinoco Jesús, Sánchez-Anguiano Luis Francisco, Antuna-Salcido Elizabeth Irasema
Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Dgo, Mexico.
Institute for Scientific Research "Dr. Roberto Rivera Damm", Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Dgo, Mexico.
Eur J Microbiol Immunol (Bp). 2017 Jul 13;7(3):229-233. doi: 10.1556/1886.2017.00013. eCollection 2017 Sep.
It is not clear whether infection with cytomegalovirus (CMV) is associated with hypertensive disorders in pregnant women. Through a case-control study design, 146 women suffering from hypertensive disorders in pregnancy (cases) and 146 age-matched normotensive pregnant women (controls) were examined for the presence of anti-CMV IgG and IgM antibodies with enzyme-linked immunoassays. IgM seropositive samples were further assayed by enzyme-linked fluorescent assay (ELFA). Anti-CMV IgG antibodies were found in 138 (94.5%) controls and in 136 (93.2%) cases (odds ratio [OR] = 0.78; 95% confidence interval [CI]: 0.30-2.05; = 0.62). High (>18 IU/ml) levels of anti-CMV IgG antibodies were found in 37.7% of the 138 seropositive controls and in 34.6% of the 136 seropositive cases (OR = 0.87; 95% CI: 0.53-1.43; = 0.59). Anti-CMV IgM antibodies were found in 1 (0.7%) of the controls but in none of the cases using ELFA ( = 1.0). Seropositivity to CMV was not associated with a previous preeclampsia and was similar among cases regardless their mean systolic and diastolic blood pressures, and mean arterial blood pressure. No serological evidence of an association between CMV infection and hypertensive disorders of pregnancy was found. Further research to elucidate the role of CMV in hypertensive disorders in pregnancy should be conducted.
目前尚不清楚巨细胞病毒（CMV）感染是否与孕妇高血压疾病有关。通过病例对照研究设计，对146例患有妊娠高血压疾病的妇女（病例组）和146例年龄匹配的血压正常的孕妇（对照组）进行酶联免疫测定，检测抗CMV IgG和IgM抗体的存在情况。对IgM血清反应阳性的样本进一步采用酶联荧光测定法（ELFA）检测。在138例（94.5%）对照组和136例（93.2%）病例组中发现了抗CMV IgG抗体（优势比[OR]=0.78；95%置信区间[CI]：0.30 - 2.05；P = 0.62）。在138例血清反应阳性的对照组中有37.7%以及136例血清反应阳性的病例组中有34.6%的个体抗CMV IgG抗体水平较高（>18 IU/ml）（OR = 0.87；95% CI：0.53 - 1.43；P = 0.59）。采用ELFA法在1例（0.7%）对照组中发现了抗CMV IgM抗体，但病例组中未发现（P = 1.0）。CMV血清反应阳性与既往子痫前期无关，且病例组中无论其平均收缩压、舒张压以及平均动脉压如何，CMV血清反应阳性情况均相似。未发现CMV感染与妊娠高血压疾病之间存在关联的血清学证据。应开展进一步研究以阐明CMV在妊娠高血压疾病中的作用。
